This federal Project Grant award for $153,540 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award supports research at Columbia University to perform human genome-wide association studies (GWAS) to identify genetic risk variants associated with urinary tract infections (UTIs). The research aims to discover novel genes and cell types involved in immune...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is funding research to develop a deep learning model that can diagnose urinary tract obstruction in children with antenatal hydronephrosis more accurately than current clinical standards. The $155,011 award, with a project period from March 15, 2025 to January 31, 2030, aims to create a multimodal...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research to explore the feasibility and methodology of performing in vivo genome editing in the urothelium (bladder lining) of live mice. The $207,000 award to New York University School of Medicine will test approaches to deliver CRISPR/Cas9 tools via transurethral...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will fund research to investigate the role of urothelial cells in bladder sensory function and pain signaling. The $521,019 award to The Medical College of Wisconsin, Inc. aims to functionally and molecularly identify the sensory neuron populations that respond to urothelial cell...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $117,000.00 to the Research Institute at Nationwide Children's Hospital to conduct research on defining the role of the STAT3 signaling pathway in mediating urothelial defense mechanisms against urinary tract infections (UTIs). The objectives of this 2-year research project are to: 1) Elucidate the mechanisms by...
This $337,284 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) will support the development of a novel "Precision-Cut Bladder Slice" (PCBS) technology at Boston Children's Hospital. The goal is to enable quantitative assessment of bladder smooth muscle contraction, relaxation, and stiffness in both healthy murine and human tissues, while...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $708,138 to support the development of a biomechanocompatible small molecule-releasing scaffold for bladder augmentation. The goal is to create an alternative to conventional surgical approaches that use detubularized bowel tissue, which can have significant complications. The...
This Project Grant award of $360,836 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) aims to improve understanding of the genetic basis of congenital obstructive uropathy (COU) and its subtypes, known as congenital anomalies of the kidney and urinary tract (CAKUT). The research conducted at the Trustees of Columbia University in the City of New York will perform the...
This Project Grant award of $690,451 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research at the University of Pittsburgh to investigate the role of fibroblasts in bladder mucosal function. The research aims to define the molecular mechanisms that allow specialized suburothelial fibroblasts to reform the bladder mucosa into rugae (folds) when the bladder...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to leverage a unique dog model to investigate the role of the protein uromodulin in kidney stone disease. The $368,500 award, effective September 1, 2024 through August 31, 2025, will support research to identify how defects in uromodulin polymerization and peptide excretion impact renal...