Project Grant R01DK136510

Award Date 8/11/24
Completion Date 7/31/28
Dollars Obligated $1.9M
Federal Grant Program
93.847
Assistance Type
Project Grant
Place of Performance
Indianapolis, IN 46202, USA
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This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) totaling $1,861,715 supports research to develop new treatment strategies for pyelonephritis (kidney infection) by examining the role of intercalated cells in the kidney's innate defense.

The research team at Indiana University Indianapolis will investigate the STAT3 signaling pathway in intercalated cells and its relationship to phagocytosis of bacteria, with the goal of understanding how to modulate intercalated cell function to better manage pyelonephritis and reduce antibiotic exposure. Specific aims include determining the dependence of the STAT3 pathway on TLR4 and JAK1 signaling, evaluating how STAT3 regulates phagosome pH, and assessing the impact of increased STAT3 activation on intercalated cell phagocytosis and kidney infection burden. This research is expected to provide a foundation for incorporating intercalated cell modulation into pyelonephritis treatment strategies beyond just using antibiotics.

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