The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $452,681 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to The Regents of the University of California, San Francisco (UCSF) for the project "Control of Mammalian Craniofacial Morphogenesis by the ESCRT Machinery". The research aims to determine the tissue-specific roles of the ESCRT machinery in regulating signaling pathways and lipid metabolism during mammalian...
This National Institute of Dental and Craniofacial Research (NIDCR) Project Grant award under the Oral Diseases and Disorders Research program (CFDA 93.121) provides $320,053 to the University of Southern California (USC) to conduct comprehensive research on the craniofacial skeleton and connective tissue development. The 8-year project will utilize advanced techniques in spatial transcriptomics and mouse genetics to identify genes and pathways regulating the assembly of the craniofacial...
The National Institute of Dental and Craniofacial Research (NIDCR) has awarded a $148,176 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to The Regents of the University of California, Berkeley. The funding will support research to uncover novel gene regulatory networks underlying craniofacial development and specialization in pupfish species. The project aims to leverage the unique evolutionary model of Cyprinodon pupfishes on San Salvador Island to...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $252,752 Project Grant (CFDA 93.121 - Oral Diseases and Disorders Research) to the Regents of the University of California, San Francisco to study the developmental and molecular functions of the TGDS gene in Catel-Manzke syndrome, a craniofacial disorder characterized by micrognathia, cleft palate, and limb/cardiovascular phenotypes. The researchers will use CRISPR/Cas9 gene editing in mice to generate an allelic...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $2,055,996 Project Grant (CFDA 93.121 - Oral Diseases and Disorders Research) to the University of Texas Health Science Center at Houston to investigate skeletal stem cell plasticity as a central mechanism of craniofacial bone formation and disease. The research program will: 1) Interrogate the fates and functions of periosteal and endosteal stem cells in load-bearing craniofacial bones under normal and regenerative...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $493,458 in funding to the Children's Hospital Medical Center in Cincinnati, Ohio. The grant supports research to investigate the cellular and molecular mechanisms that regulate the development and differentiation of cranial neural crest cells, which play a critical role in craniofacial development. The research aims to...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $645,034 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to the University of Pittsburgh. The grant aims to leverage whole genome sequencing and functional genomic characterization to improve the understanding of the genetic basis and underlying biological mechanisms of non-syndromic cleft lip and palate (NSCLP), a common birth defect affecting approximately 135,000 newborns...
This $453,750 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support research to investigate the genetic and cellular mechanisms underlying craniosynostosis, a common craniofacial birth defect. The research team at Boston University Medical Campus will use a zebrafish model to study the role of the ERF transcription factor in normal skull development and how its reduction...
This federal Project Grant award, valued at $294,000 and spanning September 2024 to September 2026, was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) program. The grant supports research to understand the mechanisms of craniofacial cartilage differentiation from human neural crest stem cells, with the goal of developing tissue engineering approaches to repair birth defects and injuries to the head and...
This $600,029 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121) aims to systematically elucidate the mechanisms underlying craniofacial and dental birth defects associated with Rasopathy syndromes. The research will leverage comparative morphometrics in human patients, transcriptomic and proteomic analyses in mouse models and human patient-derived induced pluripotent...