This Project Grant award of $3,069,994.00 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research Federal Grant Program (CFDA 93.121), supports a multi-faceted research program focused on elucidating the role of skeletal stem cell plasticity in craniofacial bone diseases. The primary awardee, the University of Texas Health Science Center at Houston, will investigate the fates and functions of periosteal and endosteal stem cells in load-bearing craniofacial bones under normal and regenerative conditions, as well as mechanisms regulating chondrocyte plasticity in the cranial base synchondrosis and mandibular condylar cartilage. Additionally, the program will explore in-depth molecular and cellular mechanisms governing skeletal stem cell plasticity in two novel craniofacial bone disease models: idiopathic condylar resorption (endochondral) and osteonecrosis of the jaw (intramembranous). The research program aims to establish skeletal stem cell dysregulation as a fundamental tenet of craniofacial bone diseases, which can serve as a critical therapeutic target. The University of Michigan is a sub-awardee supporting specific aspects of this research program.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $1.0m | 6/30/25 | ||
| Not listed | $0 | 10/28/24 | ||
| Not listed | $0 | 10/28/24 | ||
| Not listed | $1.0m | 9/20/24 | ||
| Not listed | $1.0m | 9/20/24 |
Grant Number | Description | Subgrantee | Prime Award | Dollars Obligated (Click to sort descending) | Updated At (Click to sort ascending) |
|---|---|---|---|---|---|
SA0004193S | Regents Of The University Of Michigan | Project Grant R35DE034348 | $880.0k | 10/25/24 |