Project Grant R01DE033885

Award Date 9/16/24
Completion Date 8/31/29
Dollars Obligated $453K
Federal Grant Program
93.121
Assistance Type
Project Grant
Place of Performance
San Francisco, CA 94143, USA
Similar Awards
This National Institute of Dental and Craniofacial Research (NIDCR) Project Grant award under the Oral Diseases and Disorders Research program (CFDA 93.121) provides $320,053 to the University of Southern California (USC) to conduct comprehensive research on the craniofacial skeleton and connective tissue development. The 8-year project will utilize advanced techniques in spatial transcriptomics and mouse genetics to identify genes and pathways regulating the assembly of the craniofacial...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $178,848 five-year Project Grant (CFDA 93.121 - Oral Diseases and Disorders Research) to The Regents of the University of California, San Francisco (UCSF) to study the role of the p120-catenin protein in craniofacial development and disease. The project aims to elucidate the molecular mechanisms underlying cleft lip formation, leveraging newly developed mouse models and live imaging approaches to understand how...
The National Institute of Dental and Craniofacial Research (NIDCR) has awarded a $148,176 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to The Regents of the University of California, Berkeley. The funding will support research to uncover novel gene regulatory networks underlying craniofacial development and specialization in pupfish species. The project aims to leverage the unique evolutionary model of Cyprinodon pupfishes on San Salvador Island to...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $619,304.36 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to The Children's Hospital Corporation (doing business as Boston Children's Hospital) to conduct research on mapping and predicting the effects of transcription factor dosage on craniofacial morphology and disease. The project aims to develop tools to precisely modulate the dosage of craniofacial transcription factors in...
This Project Grant award of $804,478 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support research to generate a single-cell atlas of human craniofacial development and use evolutionary analysis to identify enhancers critical for midface development. The goal is to improve understanding of the genetic basis of midface defects, including clefts of the lip and palate, which can substantially...
This federal Project Grant award, valued at $294,000 and spanning September 2024 to September 2026, was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) program. The grant supports research to understand the mechanisms of craniofacial cartilage differentiation from human neural crest stem cells, with the goal of developing tissue engineering approaches to repair birth defects and injuries to the head and...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $606,296 project grant (CFDA 93.121 - Oral Diseases and Disorders Research) to the University of Missouri System on May 1, 2025. The grant supports a 5-year research project to develop state-of-the-art, three-dimensional growth models of the craniofacial complex using advanced cone-beam computed tomography (CBCT) imaging. The goal is to create new growth standards that incorporate the three-dimensional nature of the...
This $453,750 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support research to investigate the genetic and cellular mechanisms underlying craniosynostosis, a common craniofacial birth defect. The research team at Boston University Medical Campus will use a zebrafish model to study the role of the ERF transcription factor in normal skull development and how its reduction...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $600,029 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to Cedars-Sinai Medical Center. The grant, which runs from March 10, 2025 to February 28, 2030, supports research to elucidate the molecular and cellular mechanisms by which Ras/MAPK signaling dysregulation causes abnormal enamel formation and craniofacial development. The research aims to determine how Ras signaling disruption...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $252,752.00 to The Regents of the University of California, San Francisco to conduct research on the developmental and molecular basis of Catel-Manzke Syndrome, a craniofacial condition. The research aims to pinpoint the affected developmental processes through mouse genetic and quantitative morphometric assays,...

The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $452,681 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to The Regents of the University of California, San Francisco (UCSF) for the project "Control of Mammalian Craniofacial Morphogenesis by the ESCRT Machinery". The research aims to determine the tissue-specific roles of the ESCRT machinery in regulating signaling pathways and lipid metabolism during mammalian craniofacial development. Key objectives include characterizing the impact of ESCRT-II deficiency on craniofacial morphogenesis, identifying dysregulated lipid species, and evaluating whether modulating lipid metabolism can rescue the craniofacial defects observed in ESCRT-II mutant embryos. This 5-year project seeks to uncover novel ESCRT-dependent regulators that could inform strategies for diagnosis and treatment of abnormal craniofacial development.

Generated 7/1/25, 2:50 AM