This Project Grant award of $781,032 was provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The award supports research to understand the interplay between norepinephrine and dopamine circuits in the brain and their role in sex differences related to reward and aversion, including substance use disorders. Specifically, the research aims to map the anatomical and neurochemical distribution of norepinephrine projections from...
This federal Project Grant award, funded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research to examine the link between epigenetic processes, mitochondrial function, and drug-seeking behavior in the context of nicotine use disorder. The award, totaling $169,474.00 and spanning August 2024 to July 2029, will be carried out by researchers at the University of Maryland, Baltimore. The key objectives of this research...
This Project Grant award of $1,159,396 from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research at Vanderbilt University on the molecular and epigenetic mechanisms underlying how cocaine exposure activates specific neuronal ensembles in the nucleus accumbens and how these ensembles change over time to drive addiction-related behaviors. The research aims to use innovative techniques like single-nucleus RNA sequencing and...
This $149,284 Project Grant award from the National Institute on Drug Abuse (CFDA 93.279 - Drug Use and Addiction Research Programs) to Vanderbilt University will fund research to understand how chronic cocaine use disrupts the neural processing of aversive, non-drug stimuli in the brain. The study aims to define the precise temporal parameters under which dopamine release modulates the activity of genetically-defined neuron populations in the nucleus accumbens, both at baseline and in...
This Project Grant award of $250,568.00 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) will fund a 3-year research project to investigate the neurobiological mechanisms underlying individual and sex differences in emotional cue processing related to addiction and post-traumatic stress disorder. The award recipient, the Regents of the University of Michigan, will use chemogenetic and fiber photometry techniques to gain control...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will fund research to study the neurogenetic mechanisms underlying nicotine and cannabis addiction. The $175,888 award, effective September 1, 2024 through August 31, 2028, will enable the development of novel transcriptome-connectome analysis methods to identify genes associated with changes in brain functional connectivity related to addiction. The...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $148,568 to investigate the mechanisms of dopamine transmission and its role in reward-related behaviors. The award period runs from January 1, 2025 to July 31, 2027. The funded research aims to advance the mechanistic understanding of how dopamine signaling occurs at the subcellular level, given limitations in prior methodologies. The...
This Project Grant award, valued at $136,929.00, was provided by the National Institute on Drug Abuse (NIDA) under the federal Drug Use and Addiction Research Programs (CFDA 93.279). The award supports research at Vanderbilt University to investigate the circuit mechanisms underlying inflexible habitual behaviors following chronic cocaine use. Specifically, the research aims to: 1) Determine if a history of cocaine self-administration alters dopamine release to promote habitual behavior, 2)...
This Project Grant award of $1,315,596.00 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) will fund research to understand the effects of maternal exposure to electronic nicotine delivery system (ENDS) aerosols during pregnancy on addiction-related behaviors and neurocircuitry in offspring. The project, which runs from March 2025 to December 2029, will use animal models to examine the impacts of prenatal ENDS exposure on...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will fund research to investigate the role of cholinergic interneurons in the ventral tegmental area on opioid-related behaviors. The $373,181 grant, awarded on July 15, 2024 with a completion date of June 30, 2027, aims to determine whether mu-opioid receptors on cholinergic interneurons contribute to opioid reward, consumption, and withdrawal, and how...