This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will fund research to study the neurogenetic mechanisms underlying nicotine and cannabis addiction. The $175,888 award, effective September 1, 2024 through August 31, 2028, will enable the development of novel transcriptome-connectome analysis methods to identify genes associated with changes in brain functional connectivity related to addiction. The...
This federal Project Grant award, valued at $2,187,775.00 and awarded by the National Institute on Drug Abuse (NIDA), a component of the National Institutes of Health (NIH), aims to develop novel positive allosteric modulators (PAMs) of the high sensitivity α4β2 nicotinic acetylcholine receptor (nAChR) subtypes to better understand the role of this receptor in nicotine's behavioral effects. The project, funded under CFDA 93.279 - Drug Use and Addiction Research Programs, will synthesize and...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $181,675 to The Regents of the University of Colorado, doing business as the University of Colorado-Denver, to conduct research on the nicotinic modulation of excitatory synapse development in the prefrontal cortex. The research aims to elucidate the cellular, synaptic, and molecular mechanisms involved in nicotine-induced maturation of...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $201,250 to New York University (NYU) to characterize the synaptic organization and connectivity of cholinergic interneurons in the nucleus accumbens core (NAc core) region of the mouse brain. The project aims to use anatomical, electrophysiological, and optogenetic techniques to investigate how diverse excitatory and inhibitory inputs contact...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $272,395 to The Regents of the University of California, San Francisco (UCSF) to conduct research on the molecular mechanisms by which the histone methyltransferases G9A and GLP contribute to the development of addictive behaviors. The research aims to: 1) Identify surfaces that enable the specific manipulation of G9A/GLP dimers and their...
This Project Grant award of $207,910 from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports a 3-year training program for a graduate student at the University of Michigan to research shared neurobiological mechanisms that can confer vulnerability to addiction and comorbid psychiatric disorders such as post-traumatic stress disorder. The project will utilize chemogenetic and fiber photometry techniques to examine the...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), is supporting research at Vanderbilt University to investigate the role of ovarian hormones in regulating dopamine-acetylcholine interactions in the nucleus accumbens and how this influences nicotine addiction. The $379,348 award, with a project period from September 15, 2024 to March 31, 2026, will enable the researchers to: 1) define the estrogen receptor...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $1,032,192 to Yale University to conduct research on the cell-type specific epigenomic effects of cannabis use in people living with HIV. The project aims to dissect the interactions between HIV infection and cannabis use, and identify potential druggable targets through comprehensive profiling of DNA methylation across different cell types. The...
This $284,040 Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to conduct integrated single-cell and spatial mapping of the habenula circuitry to identify projection-specific molecular pathways associated with opioid exposure. The Lieber Institute for Brain Development in Baltimore, MD will lead this research effort from September 1, 2024 to August 31, 2026. The project will generate a...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $148,568 to investigate the mechanisms of dopamine transmission and its role in reward-related behaviors. The award period runs from January 1, 2025 to July 31, 2027. The funded research aims to advance the mechanistic understanding of how dopamine signaling occurs at the subcellular level, given limitations in prior methodologies. The...