Project Grant DP2NS142715

Award Date 9/6/24
Completion Date 8/31/27
Dollars Obligated $1.4M
Funding Federal Agency
Office of the Director
Federal Grant Program
93.310
Assistance Type
Project Grant
Place of Performance
Los Angeles, CA 90095, USA
Similar Awards
This $1,444,500 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to develop new cryogenic electron microscopy (cryo-EM) methods to visualize the structural heterogeneity of ribosomes at the single-molecule level in cells. The award, effective September 2, 2024 through August 31, 2027, will enable the principal investigator to pursue strategies to extend a novel technique called 2D template...
The federal Project Grant award of $621,500 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The goal of the project is to develop new methods for combined molecular and ultrastructural imaging of neural cells and tissues using advanced nanoprobes and cathodoluminescent dyes. Specifically, the award will fund the development of (1) detergent-free...
This Project Grant from the National Institutes of Health's National Institute of Neurological Disorders and Stroke will fund the development of advanced tools for genetically targeted all-optical electrophysiology in behaving mice. Specifically, the $4,381,836 award to President and Fellows of Harvard College, doing business as Harvard University, will support efforts to co-develop two-photon excitable genetically encoded voltage indicators and a new type of two-photon voltage-imaging...
The National Institute of Neurological Disorders and Stroke (NINDS), through its Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853), awarded a $578,701 project grant to the University of California, Los Angeles (UCLA) on June 16, 2025. The goal of this 5-year project is to develop a near-infrared confocal squeezed light-field microscopy (SLIM) system capable of kilohertz volumetric imaging of neuronal action potentials in 3D. This technology is intended to...
The National Institutes of Health (NIH) Office of the Director awarded a $1,345,424 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to the Regents of the University of Michigan. The grant, effective September 10, 2024 through September 9, 2027, aims to develop a novel genetically encoded "protein ticker tape" system that enables long-term, brain-wide recording of single-cell physiology in live mice without external interfacing. The technology will leverage...
This Project Grant award of $259,095 from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), aims to develop an advanced optical imaging system capable of capturing the full electrical dynamics of thousands of neurons in the cortex and hippocampus of awake, behaving rodents. The project will leverage a combination of structured one-photon excitation and light field detection to achieve high-speed volumetric imaging of genetically encoded voltage...
This Project Grant award, valued at $481,250.00 and provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to develop a synthetic biological system to manipulate subcellular RNAs and proteins in growth cones or synapses of subtype- and context-specific neurons. The goal is to enable unique forms of subcellular functional investigation in subtype- and...
The National Institute of General Medical Sciences (NIGMS) awarded a $344,400 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to The University of Texas Southwestern Medical Center to develop new tools and approaches for improving cryo-electron microscopy (cryo-EM) and cryo-electron tomography (cryo-ET) imaging techniques. Specifically, the grant aims to: 1) Develop a sample preparation strategy to reduce electron-induced radiolysis of frozen-hydrated biological...
This Project Grant award of $517,546, awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research to optimize, benchmark, and validate a novel multimodal microelectrode array (MEA) probe that integrates fast-scan cyclic voltammetry (FSCV) for sub-second neuromodulator sensing with parallel electrical recording. The research team, led by investigators from Dartmouth College, aims to develop this integrated MEA platform...
This Project Grant award of $449,228 from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), will fund the development of an integrated system for long-term electrophysiological profiling of human brain organoids. The key products and services to be delivered include: A biological assay chamber that supports chronic electrophysiology while maintaining the health of brain organoids. High-fidelity, 3D neural probes for chronic,...

This $1,417,500 Project Grant awarded by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) funds the development of "Electrified Cryo-EM", a novel tool that can kinetically trap biological systems in their metastable, non-equilibrium states. The research aims to unravel the structural changes in neurons during an action potential across multiple length scales, from voltage-gated channel proteins to the synaptic junction. Specifically, the project will: 1) demonstrate an Electrified Cryo-EM device that can successfully trap metastable states under electrical stimulus; 2) elucidate a time series of structural changes in voltage-gated channel proteins throughout an action potential; and 3) trap the conformations of a synaptic junction between neurons during electrical stimulation. This fundamentally new approach is expected to provide unprecedented insights into neuron behavior under electrical stimulus, guiding future neurostimulation treatments for neurological diseases. The award period runs from Sep 6, 2024 to Aug 31, 2027.

Generated 7/1/25, 4:11 AM