The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $621,500 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to President and Fellows of Harvard College to develop novel nano- and immuno-probes for multicolor electron microscopy of neural cells and tissues. The project aims to establish two methods for multicolor electron microscopy: one using smaller antibody fragments (single chain variable antibody fragments, or scFvs) as immunoprobes, and another using lanthanide nanoparticles and small-molecule dyes as cathodoluminescent probes. This technology-driven approach seeks to improve the combined visualization of molecular and ultrastructural features of neural networks, with potential impact on neurobiology and medical research. The award period extends from December 2024 to November 2029.
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