This $1,444,500 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to develop new cryogenic electron microscopy (cryo-EM) methods to visualize the structural heterogeneity of ribosomes at the single-molecule level in cells. The award, effective September 2, 2024 through August 31, 2027, will enable the principal investigator to pursue strategies to extend a novel technique called 2D template...
The National Institute of General Medical Sciences (NIGMS) awarded a $291,224 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the University of Chicago to develop BRAVE-EM, a novel imaging technique that combines the wavelength specificity of optical light microscopy with the spatial resolution and volume imaging capabilities of electron microscopy. This 5-year research program, starting on August 15, 2024, seeks to enable simultaneous functional and structural imaging...
The National Institute of General Medical Sciences (NIGMS) awarded a $395,455 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Purdue University. The grant, effective August 1, 2025 through July 31, 2030, will support the development and application of computational methods for biomolecular structural modeling of cryo-electron microscopy (cryo-EM) data. Key objectives include enhancing structure modeling capabilities to improve accuracy and efficiency,...
The National Institute of General Medical Sciences (NIGMS) awarded a $3,999,999 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the Icahn School of Medicine at Mount Sinai (ISMMS). The funding will support the purchase of a Glacios 2 cryo-electron microscope (cryo-EM) to enable ISMMS researchers to conduct advanced structural biology studies on diverse biological systems and disease mechanisms. The new cryo-EM instrument, equipped with a Falcon 4i...
The National Institute of General Medical Sciences (NIGMS) awarded a $306,872 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Sindri Materials Corp, a for-profit veteran-owned manufacturer, to investigate the development of an optimized graphene-based architecture for cryogenic electron microscopy (cryo-EM) to address challenges in macromolecule imaging. The goal is to create a reliable, reproducible, and rapid cryo-EM integration solution using...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $349,999 to Denovx, LLC to adapt the company's surface science approach to improving protein crystallization for enhancing cryogenic electron microscopy (cryo-EM) specimen quality. The goal is to identify physical and chemical modifications to cryo-EM support materials that can enhance the adsorption and random orientation of...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $792,584 to Old Dominion University and its affiliated research foundation to develop multi-resolution docking methods and computational modeling tools for cryo-electron microscopy (cryo-EM) and cryo-electron tomography (cryo-ET). The 5-year project aims to advance flexible fitting and refinement of AlphaFold2 models, improve...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $349,625 to support the development of a time-resolved cryo-vitrification imaging technique called "VERITAS". The goal is to create an innovative biophysical tool that can rapidly freeze cells after stimulation, enabling high-resolution microscopy analysis of nanoscale cellular dynamics with millisecond...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $335,712 to the University of New Mexico to develop advanced imaging techniques for studying protein interactions and organizations in cells. The primary objectives are to: 1) Develop high-resolution two-color single-particle tracking (SPT) methods to investigate dimer formation and dissociation, and 2) Create a...
This $1,999,999 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will establish a Midwest Regional Cryo-Electron Microscopy (Cryo-EM) Facility at the University of Kansas Medical Center (KUMC). The award will fund the acquisition of a Glacios 200 kV Cryo-TEM equipped with a Falcon 4i detector and Selectris energy filter to provide high-resolution structural analysis capabilities for researchers...