The National Institute of General Medical Sciences (NIGMS) awarded a $344,400 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to The University of Texas Southwestern Medical Center to develop new tools and approaches for improving cryo-electron microscopy (cryo-EM) and cryo-electron tomography (cryo-ET) imaging techniques. Specifically, the grant aims to: 1) Develop a sample preparation strategy to reduce electron-induced radiolysis of frozen-hydrated biological...
The National Institute of General Medical Sciences (NIGMS) awarded a $395,455 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Purdue University. The grant, effective August 1, 2025 through July 31, 2030, will support the development and application of computational methods for biomolecular structural modeling of cryo-electron microscopy (cryo-EM) data. Key objectives include enhancing structure modeling capabilities to improve accuracy and efficiency,...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $678,000.00 to Rockefeller University to conduct research on the mechanisms of eukaryotic ribosome assembly. The project aims to develop a detailed understanding of the co-transcriptional assembly and maturation of ribosomal subunits in the nucleolus, a crucial but poorly understood early stage of eukaryotic ribosome biogenesis. The...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $316,968.00 to Emory University to study the regulation, inhibition, and quality control mechanisms of ribosomes. The 5-year project, running from June 1, 2025 to May 31, 2030, will use biochemistry and structural biology approaches to investigate three key themes: 1) translation fidelity events like miscoding and frameshift errors,...
The National Science Foundation (NSF) awarded a $1,200,000 Project Grant under the Biological Sciences (CFDA 47.074) federal grant program to The Trustees of Columbia University in the City of New York. The grant supports the development of time-resolved cryo-electron microscopy (cryo-EM) techniques to study the dynamics of diverse biological molecules like RNA polymerase, GLP1R, and the AcrB multi-drug efflux transporter. The research aims to expand the application of this method beyond the...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $658,165.00 to Triad National Security, LLC to conduct advanced research on the effects of ions on mRNA, ribosomes, and antibiotic-RNA interactions. The research aims to deepen the understanding of ribosome mechanism and mRNA regulation at the atomistic level, with a focus on the bacterial ribosome. Key areas of...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $335,712 to the University of New Mexico to develop advanced imaging techniques for studying protein interactions and organizations in cells. The primary objectives are to: 1) Develop high-resolution two-color single-particle tracking (SPT) methods to investigate dimer formation and dissociation, and 2) Create a...
The National Institute of General Medical Sciences (NIGMS) awarded a $340,920 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the Board of Regents of the University of Nebraska. The goal of this 5-year project is to develop novel top-down and native mass spectrometry approaches to directly characterize and quantify intact ribosomal proteins and determine the specialized components that assemble into heterogeneous ribosome structures. This research...
The National Institute of General Medical Sciences (NIGMS) awarded a $291,224 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the University of Chicago to develop BRAVE-EM, a novel imaging technique that combines the wavelength specificity of optical light microscopy with the spatial resolution and volume imaging capabilities of electron microscopy. This 5-year research program, starting on August 15, 2024, seeks to enable simultaneous functional and structural imaging...
The National Institute of General Medical Sciences (NIGMS) awarded a $3,999,999 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the Icahn School of Medicine at Mount Sinai (ISMMS). The funding will support the purchase of a Glacios 2 cryo-electron microscope (cryo-EM) to enable ISMMS researchers to conduct advanced structural biology studies on diverse biological systems and disease mechanisms. The new cryo-EM instrument, equipped with a Falcon 4i...