This Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) provides $1,359,000.00 to Baylor College of Medicine to conduct research on age-associated cellular and molecular adaptations that enable whole-organism rejuvenation in the highly regenerative flatworm Schmidtea mediterranea. The research aims to (1) determine how age-associated damage manifests in asexual planaria throughout their lifecycle...
This $1,039,863 National Institutes of Health National Institute on Aging project grant funds research at Harvard Medical School to reverse engineer the process of cellular senescence. The research will use new microscopy techniques to observe cell size changes and correlate protein expression and phosphorylation with senescence markers as cells transition from normal to senescent states in vitro and in vivo in young and aged mice. The same induction-maturation-death lifecycle will be studied...
This Project Grant award of $506,404.00 was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) to investigate mechanisms of local and global epigenetic changes that drive senescence and aging-associated phenotypes. Key research objectives include: Examining how enhancers are rewired during senescence and aging, focusing on large enhancer communities or "cliques" and identifying transcription factors that drive their formation....
This Project Grant award from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), aims to unravel the molecular mechanisms underlying the cellular rejuvenation process induced by partial reprogramming using the OSKM transcription factors. The $422,419 award will support research to 1) map the transcriptomic, chromatin, and epigenetic changes during OSKM-mediated partial reprogramming, and 2) identify the gene regulatory networks and key regulators...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $649,679 to the Regents of the University of Minnesota to conduct research on mechanisms of aging. The project aims to evaluate how a population of mouse T cells can be iteratively boosted and passaged among young mice for over 11 years, exceeding the normal mouse lifespan, while retaining functional competence and proliferative potential. The research will investigate factors such as...
The National Institute on Aging (NIA) awarded a $442,750 Project Grant (CFDA 93.866) to Duke University to conduct research on using heterochronic (age-mismatched) hepatocyte transplantation to rejuvenate the aged liver. The research aims to understand how transplanting young hepatocytes into old livers, and vice versa, can influence liver function, cellular composition, and the plasma proteome. Key objectives include measuring changes in liver function markers, analyzing the liver's cellular...
This federal Project Grant award from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), will support research by Tufts University School of Medicine to develop metabolomics clocks as a tool to explore the mechanisms of aging. The total funding amount is $592,507 and the award period runs from Sep 30, 2024 to Jun 30, 2029. The key objectives of the project are to: 1) develop sex- and tissue-specific metabolome clocks in the Drosophila model system that can...
The National Institute on Aging awarded a $387,068 Project Grant under its Aging Research federal grant program (CFDA 93.866) to the Icahn School of Medicine at Mount Sinai (ISMMS) to investigate the mechanisms underlying cellular rejuvenation during oogenesis. The project aims to define the spatiotemporal dynamics of nuclear pore complex (NPC) turnover, determine the factors that promote NPC rejuvenation, and assess the biological relevance of these NPC rejuvenation pathways to oocyte...
Duke University received a $1,019,484.58 Project Grant award from the National Institutes of Health's National Institute on Aging under the Aging Research program (CFDA 93.866) for the period September 1, 2021 through May 31, 2022. The award will support research using the nematode C. elegans as a model organism to study aging-associated neurodegeneration at the molecular level, with the goals of uncovering novel mechanisms underlying this process and establishing C. elegans neurons as a...
The National Institute on Aging (CFDA 93.866) awarded a $1,274,993 Project Grant to Epicypher, Inc. to develop a new approach called Reverse Transcribe & Tagmentation (RT & TAG) for identifying chromatin-associated RNAs (CARNAs), including nascent RNA transcripts, to accelerate aging and Alzheimer's disease/age-related dementia (AD/ADRD) research. The central innovation is an immunotethering-based method for in situ targeted tagmentation of CARNAs. The project also involves developing...