This federal Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) provides $1,359,000.00 to the Baylor College of Medicine in Houston, TX to uncover cellular and molecular adaptations for whole-organism rejuvenation. The key goals of the project are to (1) determine how age-associated damage manifests in the regenerative flatworm Schmidtea mediterranea throughout its lifecycle, and (2) identify the cell...
This $1,031,595 project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866). The awardee, Dana-Farber Cancer Institute, will define the landscape and mechanisms of protein redox regulation during aging. Specifically, the Institute will systematically map cysteine oxidation networks in mouse tissues to determine their role in coordinating protein complex assemblies relevant to age-related...
The National Institute on Aging has awarded a $2,624,098 Cooperative Agreement under the Aging Research Federal Grant Program (CFDA 93.866) to Harvard Medical School. The award period runs from May 15, 2024 to January 31, 2029. The project aims to conduct a comprehensive, multi-omics investigation into inter-organ communication (IOC) and its role in regulating metabolic processes and biological aging in the Drosophila model system. Key objectives include leveraging the Aging Fly Cell Atlas data,...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $649,679 to the Regents of the University of Minnesota to conduct research on mechanisms of cellular aging and longevity. The project aims to study a population of mouse T cells that can be iteratively boosted and passaged among young mice for over 11 years, retaining functionality without uncontrolled proliferation. The specific objectives are to reevaluate the Hayflick limit, assess mutational...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports a research project to explore the fundamental cellular mechanisms driving cellular senescence in macrophages. The $393,750 award, effective January 1, 2025 through November 30, 2029, will enable the University of California, Los Angeles (UCLA) to conduct a comprehensive research strategy. Key objectives include:...
The National Institute on Aging (NIA) awarded a $1,510,410 Project Grant (CFDA 93.866 - Aging Research) to Mayo Clinic in Rochester, Minnesota to conduct research on characterizing senescent cell populations in the bone microenvironment and their role in age-related bone loss. The project aims to leverage novel mouse models and advanced single-cell analysis techniques to better understand the heterogeneity of p16-positive senescent cells in the bone and their contributions to skeletal aging....
This federal Project Grant award of $506,404.00 from the National Institute on Aging (part of the Department of Health and Human Services' National Institutes of Health) under CFDA Program 93.866 (Aging Research) supports research into the mechanisms of cellular aging and age-related diseases. The key objectives of this 5-year grant, running from January 1, 2025 to December 31, 2029, are to: 1) investigate how changes in enhancer regulation and chromatin organization drive gene expression during...
The U.S. Department of Health and Human Services' National Institute on Aging awarded a $223,622 Project Grant (CFDA 93.866 - Aging Research) to The University of Texas Health Science Center at San Antonio to investigate the pathogenic effects of senescent cells on their microenvironments and their role in human brain aging and Alzheimer's disease and related dementias (ADRD). The project aims to generate spatial omics data from ADRD brains and corresponding mouse models, and leverage deep...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $133,353 to Mayo Clinic to conduct research on the molecular mechanisms of T cell surveillance and elimination of senescent cells under homeostasis and aging conditions. The key products and services delivered under this 2-year award include: Defining how different types of senescent cells utilize their secretome to sensitize human T cells for activation, survival, and retention (Aim 1)...
This award is a Project Grant provided by the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of Pittsburgh to build a research platform for assessing the senescence-associated secretory phenotype (SASP) in vivo. The $846,358 award, with a period of performance from November 15, 2024 to October 31, 2026, aims to: Assess the secretory signature of multiple cell types from the lung and liver in response to telomere dysfunction and persistent DNA damage, which are...
This $1,039,863 National Institutes of Health National Institute on Aging project grant funds research at Harvard Medical School to reverse engineer the process of cellular senescence. The research will use new microscopy techniques to observe cell size changes and correlate protein expression and phosphorylation with senescence markers as cells transition from normal to senescent states in vitro and in vivo in young and aged mice. The same induction-maturation-death lifecycle will be studied under perturbation by senolytic drugs to identify key kinases regulating senescence through phospho-mass spectrometry. Insights on new senolytic strategies and specific drugs may emerge. The award supports the Aging Research program's goal of understanding aging and age-related diseases and needs. Research will be performed September 2021 through January 2022.