This Project Grant award of $400,000 was provided by the National Institute on Aging (CFDA 93.866 - Aging Research) to The Trustees of the University of Pennsylvania. The award will fund research to develop computational methods for measuring intrinsic biological noise in single-cell sequencing data across levels of chromatin accessibility, gene expression, and transcript splicing. The research aims to investigate the relationship between epigenetic, transcriptional, and splicing noise and...
The National Institute on Aging (NIA) awarded a $422,419 Project Grant (CFDA 93.866 - Aging Research) to the University of California, Los Angeles (UCLA) to understand the cellular mechanisms that enable tissue and cellular rejuvenation. The research aims to map the changes in the transcriptome, chromatin landscape, transcription factor binding, and epigenetic age across partial cellular reprogramming induced by the OSKM transcription factors. This is expected to identify gene-regulatory and...
The National Institute on Aging (CFDA 93.866) awarded a $1,274,993 Project Grant to Epicypher, Inc. to develop a new approach called Reverse Transcribe & Tagmentation (RT & TAG) for identifying chromatin-associated RNAs (CARNAs), including nascent RNA transcripts, to accelerate aging and Alzheimer's disease/age-related dementia (AD/ADRD) research. The central innovation is an immunotethering-based method for in situ targeted tagmentation of CARNAs. The project also involves developing...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $649,679 to the Regents of the University of Minnesota to conduct research on mechanisms of aging. The project aims to evaluate how a population of mouse T cells can be iteratively boosted and passaged among young mice for over 11 years, exceeding the normal mouse lifespan, while retaining functional competence and proliferative potential. The research will investigate factors such as...
The National Institute on Aging (NIA) awarded a $1,055,313 Project Grant under the Aging Research (CFDA 93.866) federal grant program to the University of Miami. The grant will fund research to investigate how the glial ion channel CLH-1 controls organismal aging in the model organism C. elegans. The key objectives are to establish the function of glial CLH-1 that influences aging and identify the tissues and pathways regulated by glial CLH-1 in the aging process. This exploratory research is...
The National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), awarded a $3,070,537 Project Grant to the University of Maryland, College Park to develop and validate a new proteomics platform called Scalable Single-Cell Mass Spectrometry (SCEMAS). This platform aims to enable high-sensitivity mass spectrometry approaches necessary to characterize proteomic changes associated with aging, such as in neurons, neuronal subtypes, and neuronal subcompartments,...
This National Institute on Aging (CFDA 93.866 Aging Research) Project Grant award of $412,500 to the Trustees of Boston University (Boston University Medical Campus) will fund research to investigate the "vicious cycle" between disruption of chromatin architecture, activation of retrotransposable elements (RTEs), and misexpression of CpG island-deficient genes during the aging process. The research aims to validate the mutual activation between chromatin architecture disruption and RTE...
This $312,900 Project Grant award from the National Institute on Aging's Aging Research Federal Grant Program (CFDA 93.866) supports research to identify the genetic basis of extraordinary lifespan in a model organism, the nematode Caenorhabditis elegans. The 5-year project aims to: (1) discover the genetic variants responsible for longevity in a naturally occurring long-lived C. elegans isolate, (2) analyze how natural variation affects lifespan and develop tissue-specific "aging...
The National Institutes of Health's National Institute on Aging awarded $256,331.40 under the Aging Research program (CFDA 93.866) to The Trustees of the University of Pennsylvania from February to October 2021. The project aims to develop novel machine learning algorithms and biomedical software to more accurately quantify brain aging and predict the onset of neurodegenerative diseases such as Alzheimer's. Specifically, the funding will support refining predictive models of the...
This $101,925 Project Grant award was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) to investigate the role of the propionate metabolism pathway in the aging process. The 2-year project aims to: Continue studying the impact of methylmalonic acid (MMA), a metabolite in the propionate pathway, on cell senescence and aging-associated pulmonary fibrosis. Characterize a novel function of propionyl-CoA (P-CoA), another pathway...