The National Institutes of Health (NIH) Office of the Director awarded a $1,404,000 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to the Regents of the University of Michigan. The grant, titled "Turning Back Biological Clock: Mechanisms of Age Reversal in a Whole Organism," aims to investigate the molecular and cellular mechanisms underlying age reversal in the planarian S. mediterranea. Specifically, the research will examine two potential mechanisms for...
The federal Project Grant award of $1,440,000.00 was provided by the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310). The project, titled "Systematic Brain-Body Communication and Personalized Aging Trajectories," seeks to elucidate how aging affects brain-body communication at the individual level. The research will integrate an innovative single-whole-organism single-cell sequencing platform and cutting-edge machine...
This Project Grant award from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), aims to unravel the molecular mechanisms underlying the cellular rejuvenation process induced by partial reprogramming using the OSKM transcription factors. The $422,419 award will support research to 1) map the transcriptomic, chromatin, and epigenetic changes during OSKM-mediated partial reprogramming, and 2) identify the gene regulatory networks and key regulators...
The National Institute on Aging (NIA) awarded a $442,750 Project Grant (CFDA 93.866) to Duke University to conduct research on using heterochronic (age-mismatched) hepatocyte transplantation to rejuvenate the aged liver. The research aims to understand how transplanting young hepatocytes into old livers, and vice versa, can influence liver function, cellular composition, and the plasma proteome. Key objectives include measuring changes in liver function markers, analyzing the liver's cellular...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $649,679 to the Regents of the University of Minnesota to conduct research on mechanisms of aging. The project aims to evaluate how a population of mouse T cells can be iteratively boosted and passaged among young mice for over 11 years, exceeding the normal mouse lifespan, while retaining functional competence and proliferative potential. The research will investigate factors such as...
This $1,039,863 National Institutes of Health National Institute on Aging project grant funds research at Harvard Medical School to reverse engineer the process of cellular senescence. The research will use new microscopy techniques to observe cell size changes and correlate protein expression and phosphorylation with senescence markers as cells transition from normal to senescent states in vitro and in vivo in young and aged mice. The same induction-maturation-death lifecycle will be studied...
Duke University received a $1,019,484.58 Project Grant award from the National Institutes of Health's National Institute on Aging under the Aging Research program (CFDA 93.866) for the period September 1, 2021 through May 31, 2022. The award will support research using the nematode C. elegans as a model organism to study aging-associated neurodegeneration at the molecular level, with the goals of uncovering novel mechanisms underlying this process and establishing C. elegans neurons as a...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $255,420 to the Trustees of the University of Pennsylvania to conduct research on balancing cellular repair and regeneration in aging and disease. The key objectives are to: Delineate the mechanism of Hedgehog signaling in balancing autophagy and proliferation to preserve cellular aging; Define the Hedgehog-dependent transcriptome during aging, with a focus on genes dysregulated in cancers...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $1,055,313 in funding to the University of Miami to conduct research on the role of glial cells in the aging process. Specifically, the researchers will leverage C. elegans genetics and advanced imaging and supplementation methods to investigate how the glial ion channel CLH-1 controls organismal aging. The key objectives are to establish the function of glial CLH-1 in influencing aging and to...
This federal Project Grant award from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), will support research by Tufts University School of Medicine to develop metabolomics clocks as a tool to explore the mechanisms of aging. The total funding amount is $592,507 and the award period runs from Sep 30, 2024 to Jun 30, 2029. The key objectives of the project are to: 1) develop sex- and tissue-specific metabolome clocks in the Drosophila model system that can...