Project Grant 2612061
- The National Science Foundation Division of Molecular and Cellular Biosciences awarded New York University $1.3 million on June 1, 2026, under the Biological Sciences program (CFDA 47.074) to develop SYNTACS (Synthetic Transcriptional Architecture of Condensates and Super-Enhancers), a research initiative testing how the linear organization of regulatory DNA elements encodes transcriptional control in human cells. The project systematically re-engineers the spacing, density, and orientation of...
- This $1,000,000 Project Grant award from the National Science Foundation's Biological Sciences (CFDA 47.074) program supports research by the University of California, San Francisco (UCSF) to design, build, and test synthetic signaling systems built from computationally-designed de novo protein components. The goal is to develop stable, tunable, and modular signaling systems capable of precisely controlling biological processes, with applications in biotechnology such as engineered cells for...
- The National Science Foundation Division of Molecular and Cellular Biosciences awarded California Institute of Technology $1,299,997 on July 1, 2026, to develop predictive mathematical models of cell signaling pathways and their role in cellular communication and identity specification. This Project Grant funds research under the NSF Biological Sciences program (CFDA 47.074). The recipient will investigate how combinatorial signaling—the ability of different combinations of signaling proteins to...
- The National Institute of General Medical Sciences awarded The Regents of the University of California, doing business as University of California, Berkeley, $425,364 on August 17, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate unconventional gene regulatory mechanisms in meiosis and related cellular differentiation processes. The research focuses on how cells coordinate simultaneous activation and repression of distinct gene clusters during...
- The National Science Foundation Division of Molecular and Cellular Biosciences awarded the University of California, San Diego $800,000 on June 15, 2026, under the Biological Sciences program (CFDA 47.074) to systematically identify, functionally characterize, and solve high-resolution structures of RNA tertiary motifs in human cells. The research addresses a significant gap in understanding human gene regulation by using innovative chemical probing technology to discover and visualize...
- The National Science Foundation Division of Molecular and Cellular Biosciences awarded the University of California, Berkeley $180,426 on July 1, 2026, under the Biological Sciences program (CFDA 47.074) to structurally characterize the nucleocapsid-mediated packaging of the SARS-CoV-2 genome using nuclear magnetic resonance methods. The research integrates magic angle spinning (MAS) and dynamic nuclear polarization (DNP) NMR techniques to overcome current challenges in studying complex...
- The National Science Foundation Division of Molecular and Cellular Biosciences awarded $1.2 million to the University of California, Davis on July 15, 2026 under the Biological Sciences program (CFDA 47.074) to fund research on gene-specific nuclear messenger ribonucleoprotein (mRNP) assembly and quality control. The project investigates how information encoded in genes is transported within cells to direct protein production at appropriate times and locations. The research focuses on defining...
- The National Science Foundation Division of Molecular and Cellular Biosciences awarded The Leland Stanford Junior University $1 million on July 1, 2026, under the Biological Sciences program (CFDA 47.074) to investigate how enhancer networks control gene expression through chromosomal organization and dynamics. The research integrates genomic perturbation using CRISPR technology, live-cell fluorescent imaging to observe DNA movement in real time, and computational modeling combining...
- The National Science Foundation Division of Molecular and Cellular Biosciences awarded Brandeis University $370,052 on August 1, 2026, under the Biological Sciences program (CFDA 47.074) to investigate how intrinsically disordered regions in proteins regulate the search and binding of heterochromatin-associated proteins in living cells. The research aims to determine how dynamic recruitment and retention of histone H3 lysine 9 methylation-binding proteins establish stable and heritable gene...
- This $1,220,400 Project Grant awarded by the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences supports a collaborative research project between investigators in the U.S. and U.K. to better understand the regulatory mechanisms controlling mammalian gene expression. The project, funded through NSF's Biological Sciences program (CFDA 47.074), aims to define the roles of different DNA regulatory elements and how they work together to precisely control gene expression....
The National Science Foundation Division of Molecular and Cellular Biosciences awarded The Regents of the University of California, doing business as University of California, Berkeley, $1.2 million on August 1, 2026, under the Biological Sciences program (CFDA 47.074) to conduct synthetic dissection of signal-to-transcription dynamics in the Notch regulatory circuit. The research combines synthetic biology, quantitative live-cell imaging, statistical inference, and mathematical modeling to establish a quantitative framework linking signaling dynamics, regulatory DNA architecture, and transcriptional bursting. The project exploits the Notch signaling pathway's architectural simplicity to test how regulatory DNA architecture and signaling dynamics control gene expression. The first research objective uses synthetic regulatory DNA sequences with precisely defined numbers, affinities, and arrangements of Notch binding sites to determine how DNA architecture controls the duration, amplitude, and frequency of transcriptional bursts in developing fruit fly embryos. The second objective develops new live-imaging methods to advance understanding of how Notch signaling controls transcriptional regulation. The research integrates investigators from the United States and Israel across biology, physics, mathematics, and engineering disciplines and includes sustained research training for undergraduate students, graduate students, postdoctoral researchers, and high school students through mentored research experiences. Performance takes place in Berkeley, California from August 1, 2026, through July 31, 2029. The award is classified as a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.2m | 7/27/26 |