The National Science Foundation (NSF) awarded a $1,000,000 Project Grant under the Biological Sciences (CFDA 47.074) program to The Regents of the University of California, San Francisco (UCSF) to design, build, and test synthetic signaling systems built from computationally designed de novo protein components. The goal is to develop synthetic membrane signaling systems capable of programmable receptor clustering, tunable signal amplification, and bidirectional transmembrane signaling. This research aims to provide insights into fundamental cellular processes and enable new biotechnology applications, such as engineering cells as sentinels or for synthetic cell-cell communication. The award period is from August 1, 2024 to July 31, 2027, and the project will also involve synthetic biology training and consideration of ethical and biosafety/security aspects of the AI-based protein engineering approach.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $1.0m | 7/30/24 |