This $1,220,400 Project Grant awarded by the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences supports a collaborative research project between investigators in the U.S. and U.K. to better understand the regulatory mechanisms controlling mammalian gene expression. The project, funded through NSF's Biological Sciences program (CFDA 47.074), aims to define the roles of different DNA regulatory elements and how they work together to precisely control gene expression. The research will generate and analyze new mouse genetic models based on the alpha-globin regulatory domain, leveraging advances in de novo DNA design, genomic engineering, and analysis. The goal is to transform understanding of the "code for life" and enable the synthesis of minimal, fully functional mammalian genomes. The U.S. work will be conducted by investigators at New York University School of Medicine, a private non-profit research institution.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $1.2m | 7/28/23 |