Project Grant 2545832
- Federal Grant Award Summary The National Science Foundation's Division of Molecular and Cellular Biosciences awarded $350,000 under the Biological Sciences program (CFDA 47.074) to Trustees of Tufts College for the TOOLS4CELLS project, effective August 1, 2025, through July 31, 2026. This Project Grant supports the development of turn-on biosensors (TOBS)—a novel measurement technology enabling real-time detection of endogenous biomolecules in live cells. The primary deliverable is the...
- This National Science Foundation (NSF) Engineering program (CFDA 47.041) Project Grant of $545,000 awarded May 15, 2025, supports research to enhance recombinant protein production in Komagataella pastoris (Pichia pastoris), a food-safe yeast widely utilized in biomanufacturing and biological research. The research will deliver scientific outcomes demonstrating how codon usage patterns can be exploited to maximize recombinant protein expression while simultaneously preserving host cellular...
- Federal Grant Award Summary Trustees of Tufts College received a $1.0 million Project Grant award from the National Science Foundation's Division of Integrative Organismal Systems under the Biological Sciences program (CFDA 47.074), effective August 15, 2025, with a completion date of July 31, 2029. The primary research deliverable is a comprehensive scientific investigation into inter-tissue signaling mechanisms, specifically examining how muscle-secreted factors regulate glutamate receptor...
- Federal Grant Award Summary The National Science Foundation's Division of Chemical, Bioengineering, Environmental, and Transport Systems (Engineering program, CFDA 47.041) awarded Tufts College $174,112 on July 1, 2025, for a collaborative research project focused on developing photonic-integrated-circuit two-photon (PIC-2P) microscopy technology. The primary deliverable is an ultra-compact, chip-scale device utilizing optical nanostructures to overcome current depth penetration limitations in...
- Federal Project Grant Award Summary Trustees of Tufts College received a $256,616 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) effective September 1, 2025, with completion targeted for August 31, 2029. The award supports the development of a comprehensive graph theory toolbox designed to analyze genetic interaction networks and uncover redundant biological pathways. The research...
- Federal Project Grant Award Summary The Trustees of Boston University received a $885,642 Project Grant from the National Science Foundation's Division of Molecular and Cellular Biosciences (Biological Sciences Program, CFDA 47.074) effective September 1, 2025, through August 31, 2028. The award supports research to characterize signal propagation and control within gene regulatory networks using optogenetic techniques. The primary deliverables include foundational scientific knowledge regarding...
- Federal Project Grant Award Summary The National Science Foundation (NSF) Engineering directorate (CFDA 47.041) awarded $303,437 to Tufts College effective October 1, 2025, with completion targeted for February 28, 2027. This project grant supports research and development of magnetically driven, bioinspired soft microrobots modeled on sperm cell swimming mechanics. The research deliverables include experimental fabrication of soft microrobots using high-resolution three-dimensional printing,...
- The National Science Foundation awarded Tufts University a $583,993 project grant under the Engineering program (CFDA 47.041) to develop superoptimal biocatalysts for the period of October 1, 2022 to September 30, 2025. The university will evaluate a new computational and materials-based strategy to design enzyme variants with improved properties without trade-offs by relaxing stability criteria and targeting non-cognate substrates. Tufts researchers will use directed evolution and deep...
- Federal Project Grant Award Summary The University of Massachusetts received a $401,490 Project Grant from the National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems under the Engineering program (CFDA 47.041), effective May 15, 2025 through April 30, 2028. The award supports the development of a modular toolset for imaging cellular metabolites using fluorogenic RNA riboswitches. This project will engineer genetically encodable, RNA-based...
- Summary of Federal Project Grant Award Harvard College's President and Fellows received a $1.275M project grant from the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences under the Biological Sciences program (CFDA 47.074), awarded July 15, 2026, with completion targeted for June 30, 2031. The primary deliverable is fundamental research into lycopodium alkaloid biosynthesis from medicinal clubmoss plants, with the objective of developing engineering strategies to...
The National Science Foundation's Directorate for Engineering (CFDA 47.041) awarded Trustees of Tufts College a $650,000 Project Grant effective July 1, 2026, through June 30, 2029, to develop engineered HEK293 (human embryonic kidney) cells with improved productivity and genetic stability for biopharmaceutical manufacturing. The primary deliverable is a quantitative framework and design principles for optimizing codon usage in recombinant protein production. Through systematic sensitivity analysis of all 61 sense codons (Aim 1), researchers will identify codons that minimize translational resource competition and stress on host cells while maintaining high protein output. In Aim 2, the project will evaluate long-term genetic stability of optimized coding schemes to ensure sustained production capacity over extended culture periods. Beyond technical outputs, the grant supports workforce development by training undergraduate, graduate, and high school students in synthetic biology and bioengineering. The research is positioned to reduce production losses and cell death in vaccine and therapeutic protein manufacturing platforms, directly addressing a critical bottleneck in biopharmaceutical production. The work will be performed at Tufts College in Medford, Massachusetts.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $650.0k | 7/1/26 |