The National Science Foundation's Division of Chemical, Bioengineering, Environmental, and Transport Systems (Engineering program, CFDA 47.041) awarded Tufts College $174,112 on July 1, 2025, for a collaborative research project focused on developing photonic-integrated-circuit two-photon (PIC-2P) microscopy technology. The primary deliverable is an ultra-compact, chip-scale device utilizing optical nanostructures to overcome current depth penetration limitations in two-photon microscopy. This technology addresses a critical challenge in biomedical imaging: light scattering through living tissues limits visualization depth when observing individual cells. By employing longer wavelengths characteristic of two-photon microscopy combined with minimally-invasive nanophotonic chip delivery systems with cellular-scale thickness, the project will enable faster tissue imaging over larger volumes using a chip-scale microscope format.
The research is expected to advance fundamental understanding of cell behavior and biology through enhanced imaging capabilities, with potential applications in improved diagnostics and therapeutics. The project is classified as an EAGER (Early-concept Grants for Exploratory Research) award, reflecting its innovative and exploratory nature. The performance period extends through June 30, 2027, with research activities conducted at Tufts College's Somerville, Massachusetts facility. The collaborative nature of the award indicates engagement with multiple research institutions, typical of NSF Engineering program grants that often involve multi-institutional partnerships to advance high-impact engineering innovation.