Project Grant 2439125
- This National Science Foundation (NSF) Biological Sciences Federal Grant Program (CFDA 47.074) Project Grant award of $360,000 to the University of Alabama at Birmingham (UAB) aims to uncover the role of neuron-to-neuron communication in the post-mitotic maturation of neurons during postnatal development. Utilizing the model organism Caenorhabditis elegans, the project will leverage advanced genetics, behavioral assays, microscopy, and genomics tools to examine the molecular and functional...
- This $715,500 federal Project Grant awarded by the National Science Foundation's (NSF) Engineering program will support research at the University of Illinois to investigate the relationship between exercise and cognitive health. The project aims to determine how muscle contraction during exercise may influence the activity and growth of cells in the hippocampus, the part of the brain involved in memory and learning. The research will conduct in vitro experiments culturing mouse muscle and...
- This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Project Grant award of $750,000.00 will investigate how the central nervous system of vertebrates produces coordinated leg movements. Specifically, the project will use the turtle spinal cord as a model system to pharmacologically perturb inhibitory and excitatory neurotransmitter receptors to understand how the spinal cord generates and selects appropriate motor outputs for swimming, scratching, and leg withdrawal...
- This National Science Foundation Project Grant of $790,344 awarded on July 1, 2022 will fund research at the University of California, San Diego examining the role of postsynaptic neurotransmitter receptors in influencing presynaptic neurotransmitter identity through retrograde signaling. The research, to be completed by June 30, 2025, aims to test the hypothesis that retrograde signaling from postsynaptic receptors stabilizes presynaptic neurotransmitter expression. It will investigate...
- This $399,996 Project Grant awarded by the National Science Foundation's Biological Sciences (CFDA 47.074) program will support research at Saint Joseph's University to explore the mechanisms underlying stress responses and sleep regulation in the model organism Caenorhabditis elegans. The project aims to characterize new neural circuit mechanisms that control avoidance behaviors and recovery sleep in response to threats. The research will be conducted primarily by undergraduate and...
- The National Science Foundation (NSF) awarded a $550,000 Project Grant under the Biological Sciences (CFDA 47.074) federal grant program to Georgetown University. The 5-year grant, effective April 1, 2025, supports research to understand how changes in the extracellular matrix surrounding synapses affect synapse stability and brain function. This work aims to uncover the mechanisms that preserve brain connectivity, with potential to inspire new strategies for addressing neurological disorders...
- This Project Grant award of $100,272.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to understand how axon guidance is regulated in the mature nervous system. The research aims to identify molecular and cellular mechanisms that regulate axon regeneration and guidance, with a focus on using the Caenorhabditis elegans model system to study an...
- This Project Grant award from the National Science Foundation's (NSF) Biological Sciences (CFDA 47.074) Federal Grant Program provides $500,000.00 to the Massachusetts Institute of Technology (MIT) from September 1, 2025 to August 31, 2028. The award will support a systematic study of the neural control of larval settlement in the genetically tractable jellyfish species Clytia. This research aims to gain a deeper understanding of the underlying neural mechanisms that govern the free-swimming...
- This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Project Grant award of $1,000,000 to the University of Michigan provides funding from August 1, 2024 to July 31, 2028 to study the molecular mechanism of telomere maintenance in the model organism Caenorhabditis elegans. The research aims to leverage the simplicity of the worm's shelterin protein complex to answer fundamental questions about the structure and function of these proteins in chromosome end protection and...
- This five-year, $649,659 National Science Foundation Engineering Project Grant will support research at the Massachusetts Institute of Technology to advance fundamental understanding of the tissues that produce voluntary movement in humans and other biological creatures. Specifically, the grant will fund experiments studying how mechanical signaling coordinates assembly, maturation and repair at the neuromuscular interface in both physiological and pathological states. The principal investigator...
This Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) provides $1,000,000 in funding to Tufts University to study how a factor secreted from muscle regulates levels of neurotransmitter receptors in neurons that control movement in the roundworm Caenorhabditis elegans. The research aims to advance scientific understanding of how muscle releases factors that signal to the brain to control communication between neurons, which may provide insights into the beneficial effects of exercise on learning, memory, and cognition. The award runs from August 15, 2025 through July 31, 2029 and includes an outreach plan to develop hands-on lab research modules for undergraduates and a summer research activity for local middle school students to learn about neuroscience. The project leverages the compact and defined nervous system of roundworms to study the muscle-to-neuron signaling pathway in live, intact animals.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.0m | 7/28/25 |