The National Science Foundation awarded a $647,764 Project Grant to Tufts University under the Engineering federal grant program (CFDA 47.041). The grant will fund research from July 2021 to June 2026 to understand the effects of surface coverage and catalyst composition on vinyl acetate synthesis. The NSF aims to improve engineering innovation, creativity and excellence through this program. The research supported by this award seeks to gain fundamental insight into catalyst properties and...
The National Science Foundation (NSF) awarded a $320,000 Project Grant under its Mathematical and Physical Sciences (CFDA 47.049) program to Tufts University. This 3-year collaborative research project, led by principal investigators at Tufts University and Tulane University, aims to explore a novel class of dual-atom alloy catalysts for efficient and selective chemical conversions. Through a combination of computational modeling using machine learning and density functional theory, as well as...
The National Science Foundation Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded a $388,369 Project Grant to the Regents of the University of Minnesota to support research extending the catalytic activity of enzymes to unnatural reactions from May 15, 2021 through April 30, 2024. Under the grant, the University of Minnesota will conduct research exploring how to engineer enzymes to catalyze reactions not found in nature, with the goal of expanding the...
This National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems (CBET) Project Grant of $579,734 awarded to Rutgers, The State University, aims to accelerate the design and development of synthetic enzymes through a combination of artificial intelligence, polymer science, and robotics. The project will implement an iterative design-build-test-learn process to reveal the underlying structure-function relationships that can produce enzyme mimetic...
The National Science Foundation Division of Materials Research awarded Tufts University a $525,000 Project Grant under the Mathematical and Physical Sciences program (CFDA 47.049) to support research titled "DYNAMIC PROTEIN-BASED BIOMATERIAL DESIGNS FOR BIONIC COATINGS" from June 15, 2021 through May 31, 2024. The grant funds research into developing dynamic protein-based biomaterial designs that can be used for bionic coatings. The Mathematical and Physical Sciences program aims to...
The National Science Foundation (NSF) awarded a 5-year, $480,730 CAREER grant under the Engineering program (CFDA 47.041) to Tufts University to evaluate the impact of modifying antibodies with unique amino acids on the regulation of matrix metalloproteinase (MMP) activity. The goal is to establish principles of "chemically diversified" antibodies that enable next-generation protease inhibitor discovery. The project will integrate noncanonical amino acids and yeast display technology...
This two-year, $200,000 Project Grant from the National Science Foundation's Division of Chemical, Bioengineering, Environmental, and Transport Systems will fund research at the Long Beach Research Foundation to develop multi-activity proteins for improved carbohydrate deconstruction. Specifically, the Foundation will produce and test 85 engineered multi-activity proteins containing two catalytic domains each. These proteins aim to increase biomass conversion for alternative fuels and...
This Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) will fund a $575,765 research project at Northeastern University to develop metabolic engineering strategies that enhance the production of biochemicals from single-carbon (C1) feedstocks using anaerobic bacteria. The key objectives are to: 1) understand the metabolic and regulatory mechanisms by which these bacteria, called acetogens, can synergistically use multiple carbon substrates to...
This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $274,918 to Cascade Biocatalysts Inc. will fund research and development to demonstrate the commercial feasibility and scalability of a patent-pending approach for stabilizing enzymes through engineered polymer-enzyme interactions. The goal is to enable environmentally sustainable, low-carbon chemical manufacturing processes that utilize enzymes as catalysts, which can decrease...
The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences and the Division of Chemical, Bioengineering, Environmental and Transport Systems awarded a $240,000 Project Grant to the University of California Irvine (UC Irvine) under the NSF Biological Sciences program (CFDA 47.074). The grant supports collaborative research to develop unnatural cofactors that can be deployed as stronger-than-nature thermodynamic driving forces in biomanufacturing processes. This is...