Project Grant 2533553
- This National Science Foundation (NSF) Project Grant under the CFDA program "Biological Sciences" (47.074) is awarded to Trustees of Boston University to develop and optimize optogenetic tools for selecting bacterial cells based on dynamic, time-varying traits. The $796,158 award, effective August 1, 2023 through July 31, 2026, supports the researchers in creating light-inducible genetic constructs that trigger antibiotic resistance, enabling the isolation of bacteria exhibiting...
- This federal Project Grant award from the National Science Foundation (NSF) Biological Sciences (CFDA 47.074) program provides $683,122 to Trustees of Boston University to develop a novel computational framework called BOLTZNET. This framework combines neural networks and biophysical modeling to quantitatively and predictively analyze gene regulation based on genomic data. The research aims to advance the understanding of how, when, and why specific genes are expressed as proteins, with...
- This $519,071 federal Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) will fund research at Boston University to explore using light to control metabolic pathways in microorganisms. The goal is to balance the production of valuable biochemical products with normal cell growth, enabling more sustainable bioprocessing. Key aspects of the research include developing novel light-responsive enzymes and comprehensively testing light induction strategies...
- The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $647,750 Project Grant to Princeton University under the Biological Sciences grant program (CFDA 47.074) to develop a closed-loop control system for regulating microbial communities. The project aims to integrate optogenetic controls and metabolite biosensing to dynamically modulate the composition and productivity of synthetic microbial communities for the production of valuable chemicals. The...
- The National Science Foundation awarded a $138,000 Project Grant to support research activities from November 1, 2021 to October 31, 2023 under the Biological Sciences program (CFDA 47.074). The grant funding will enable the grantee to conduct research at the University of Pittsburgh aimed at furthering understanding of the evolution of gene regulatory networks through empirical and theoretical approaches. The Biological Sciences program seeks to advance the field and strengthen the national...
- This $1,000,000 Project Grant award from the National Science Foundation's Biological Sciences (CFDA 47.074) program supports research by the University of California, San Francisco (UCSF) to design, build, and test synthetic signaling systems built from computationally-designed de novo protein components. The goal is to develop stable, tunable, and modular signaling systems capable of precisely controlling biological processes, with applications in biotechnology such as engineered cells for...
- The National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Federal Grant Program awarded a $987,578 project grant to The Johns Hopkins University with a project period from July 1, 2025 to June 30, 2028. The research project seeks to obtain quantitative information about the signaling properties of a member of the receptor tyrosine kinase family in response to different ligands. Highly quantitative biophysical methods will be used to understand how diverse extracellular signals...
- This three-year, $376,264 project grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research to develop new genetically engineered biological circuits and sensors. The University of Colorado Boulder team, led by The Regents of the University of Colorado, aims to harness plant hormone receptors to rapidly design genetic circuits controlled by user-specified ligands. They will engineer novel plant-derived chemical sensors that can recognize...
- This Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) provides $243,764 to the University of Massachusetts Boston to create a computational framework for understanding complex biological processes. The project will develop automated methods to construct causal models from large biological datasets, enabling researchers to uncover cause-and-effect relationships that drive cellular events. This work will accelerate discoveries across...
- The National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Federal Grant Program awarded Massachusetts Institute of Technology (MIT) a $1,041,774 project grant to conduct collaborative research on the ability of cells to store analog information in their chromatin state. The project aims to develop a model-driven approach to understand the molecular mechanisms that enable analog versus binary memory of gene expression. Key activities include training graduate and undergraduate...
The National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Federal Grant Program is providing $885,642.00 in funding to Trustees of Boston University to conduct a project titled "USING OPTOGENETICS TO CHARACTERIZE SIGNAL PROPAGATION AND CONTROL WITHIN GENE REGULATORY NETWORKS". The project aims to define the underlying principles behind the function of complex biological sensor and regulatory networks, with the goal of using this knowledge to create synthetic organisms for biotechnology, biomedicine, and agriculture applications. Key activities include using an optogenetic strategy to test how dynamic input signals are propagated within increasingly complex regulatory networks, both in well-defined synthetic circuits and the endogenous phop stress response network. The project also includes educational outreach activities, such as a multi-day workshop for high school students to introduce concepts from synthetic biology, electrical circuit design, and data analysis. This research effort is expected to run from Sep 1, 2025 through Aug 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $885.6k | 8/18/25 |