Project Grant 2540466
- Federal Project Grant Award Summary The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a collaborative research project grant of $171,000 to The Regents of the University of Colorado on June 15, 2026, under the Biological Sciences program (CFDA 47.074). The project, "Collaborative Research: Long-Range Signaling and Computation in Microtubules," will be executed through May 31, 2029. This project grant supports basic research investigating a...
- Federal Project Grant Award Summary The National Science Foundation's Division of Molecular and Cellular Biosciences awarded Massachusetts General Hospital $298,662 on June 15, 2026, under the Biological Sciences program (CFDA 47.074) to conduct collaborative research on long-range signaling and computation in microtubules. The research project, scheduled for completion by May 31, 2029, will deliver fundamental scientific findings and methodologies challenging the conventional understanding of...
- Federal Project Grant Award Summary The National Science Foundation's Division of Molecular and Cellular Biosciences awarded $1.49M to The Regents of the University of Colorado (Boulder) under the Biological Sciences program (CFDA 47.074) on June 15, 2026, with completion scheduled for May 31, 2030. This collaborative research project focuses on elucidating the regulatory mechanisms of cyclin-dependent kinase 7 (CDK7) in controlling RNA polymerase II (RNAPII) transcription termination and RNA...
- Federal Project Grant Award Summary The National Science Foundation's Division of Molecular and Cellular Biosciences awarded a $849,969 Project Grant to the University of Cincinnati on August 1, 2025, under the Biological Sciences program (CFDA 47.074) to conduct fundamental research on microtubule lattice allostery and protein-protein interactions. The four-year research initiative (through July 31, 2029) employs multi-scale computational modeling, machine learning, and experimental...
- Federal Project Grant Award Summary The University of Colorado, operating through its Office of Contracts and Grants Division in Boulder, Colorado, received a $1.058 million Project Grant from the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences under the Biological Sciences program (CFDA 47.074). Awarded July 1, 2026, with completion targeted for June 30, 2030, this grant supports fundamental research investigating the emergence of novel metabolic pathways...
- Federal Project Grant Award Summary Rensselaer Polytechnic Institute received a $251,498 Project Grant award from the National Science Foundation (NSF), Division of Molecular and Cellular Biosciences, under the Biological Sciences program (CFDA 47.074) on June 15, 2026. The award supports collaborative research investigating long-range signaling and computation in microtubules, with work to be completed by May 31, 2029. The research will deliver fundamental scientific knowledge through an...
- Federal Grant Award Summary The University of Colorado-Denver received a $296,757 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded July 10, 2026, with a completion date of April 30, 2030. This award funds fundamental research investigating how tubulin and kinesin gene families generate molecular specialization within microtubule networks. The research addresses two critical knowledge...
- Federal Project Grant Award Summary The University of Colorado-Denver received a $491,215 Project Grant from the National Science Foundation (NSF) Division of Biological Infrastructure under the Biological Sciences program (CFDA 47.074), awarded August 15, 2026, with a completion date of July 31, 2029. The grant supports collaborative research to develop DeepSPIRAL, an innovative two-photon single-molecule localization microscopy technique designed to achieve super-resolution imaging at...
- The Regents of the University of Colorado received a three-year, $1,149,515 Project Grant award from the National Science Foundation Division of Molecular and Cellular Biosciences to support research titled "Nanomechanics of Tubulin Extraction from Microtubules and Adhesin Catch-Bond Rupture." The grant is part of NSF's Biological Sciences program (CFDA 47.074), which aims to advance fundamental knowledge in biology and strengthen the Nation's scientific enterprise. Under this award,...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded The Regents of the University of Colorado a Project Grant of $426,262 under the Biomedical Research and Research Training program (CFDA 93.859) for computational modeling and measurement research on mitotic spindle length control, stability, and elongation. The award, effective July 1, 2026, through March 31, 2030, supports basic research aimed at understanding the interplay between force and...
The National Science Foundation's Division of Molecular and Cellular Biosciences awarded $478,840 to The Regents of the University of Colorado (University of Colorado-Denver) on June 15, 2026, under the Biological Sciences program (CFDA 47.074) to support collaborative research on long-range signaling and computation in microtubules. The project, which runs through May 31, 2029, will deliver fundamental research integrating computational modeling with single-molecule and cellular-level experiments to test the hypothesis that individual microtubule polymers function as transmitters and amplifiers of conformational signals within cells—a paradigm shift from their conventional characterization as purely structural elements. Findings will be documented through peer-reviewed publications, computational models, and experimental datasets. This research addresses a critical gap in cell biology by investigating how conformational changes propagate along microtubule length, potentially opening new mechanisms for understanding neuronal communication, mechanical signaling in cancer biology, and bioengineering applications where microtubules could function as responsive molecular computing systems. The project has implications across multiple scientific disciplines, including developmental biology, neuroscience, cancer biology, and bioengineering. Work will be performed in Aurora, Colorado, with the interdisciplinary research plan designed to advance understanding of cellular communication pathways and inform long-term strategies for addressing chemotherapeutic drug resistance in cancer treatment.Federal Project Grant Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $478.8k | 6/25/26 |