Project Grant 2527485
- The University of Cincinnati was awarded an $851,499 National Science Foundation Project Grant under the Biological Sciences federal grant program (CFDA 47.074) for research titled "NSF-BSF: SYNERGISTIC MULTISCALE MODELING AND SINGLE-MOLECULE FLUORESCENCE STUDIES OF THE DYNAMICS AND FUNCTION OF AAA+ PROTEIN DISAGGREGATION MACHINES." The research will involve multiscale modeling and single-molecule fluorescence studies to examine the dynamics and function of AAA+ protein...
- This National Science Foundation Project Grant award of $138,000 provides funding from August 1, 2022 to July 31, 2024 to support an NSF Postdoctoral Fellowship in Biology. The fellowship will fund research and training under the Biological Sciences program (CFDA 47.074) to define the biochemical mechanisms of microtubule shrinking and nucleation through innovative experiments and simulations. The fellow will combine wet lab experiments with computational simulations to determine how new...
- This federal Project Grant award of $125,000.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports a research project at the University of California, San Diego (UCSD) to investigate how microtubule dynamics are regulated at the cellular cortex, the interface between the plasma membrane and cytoskeleton. The primary objectives of the project are to: 1) Examine the mechanisms by...
- The National Science Foundation (NSF) awarded a $630,000 Project Grant under the Biological Sciences (CFDA 47.074) federal grant program to the University of New Mexico (UNM) to develop an advanced optical microscopy system. The project aims to significantly improve the study of protein clustering and interactions on cell membranes, which could advance the understanding of cell signaling and related diseases like cancer. The highly interdisciplinary research will combine the MINFLUX and modal...
- This $431,614 project grant was awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports research to investigate the biochemical and structural mechanisms of alpha/beta tubulin biogenesis and microtubule polymerization regulators, and their impact on microtubule function. The research aims to advance the understanding of the cellular regulation pathways governing the dynamic microtubule...
- This $526,873 federal Project Grant award from the National Science Foundation's Biological Sciences (CFDA 47.074) program supports research at the University of California, Riverside on the mechanisms of protein-protein associations facilitated by molecular "glues". The research aims to computationally model and experimentally investigate how these molecular glues mediate the formation of protein complexes and enhance their biological functions. The project will contribute to...
- This National Science Foundation Project Grant of $536,946 will support research at the University of California, San Diego from September 2022 through August 2025 under the Mathematical and Physical Sciences program (CFDA 47.049). The award will fund the development of rigorous scientific theories and powerful computational tools to model biomolecular interactions. Researchers will design advanced numerical methods to simulate drug and protein binding/unbinding kinetics, incorporating molecular...
- This federal Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) in the amount of $100,000 will support collaborative research to develop deep learning-based "consistency models" that can simulate protein dynamics over long time scales. The goal is to overcome the limitations of current molecular dynamics simulation methods, which are constrained by the need for tiny time steps, in order to unlock new insights into protein behavior and...
- The Project Grant award of $528,000.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will support research to reveal the molecular basis of microtubule-intermediate filament interactions. The research will focus on understanding how microtubules and neurofilaments, which are key cytoskeletal components in myelinated axons, are adapted to form specialized cytoskeletal arrays that regulate cell shape and...
- This National Science Foundation Project Grant of $740,498 will support research titled "TRANSITIONS: A UNIFIED CELLULAR AND IN VITRO APPROACH TO DISCOVER MOLECULAR MECHANISMS OF MICROTUBULE DYNAMICS AND REGULATION" from January 15, 2023 through December 31, 2025. The principal investigator at the University of Texas Southwestern Medical Center will receive training in modern genetics and imaging methods to study microtubules, which provide structure and shape to eukaryotic cells....
This federal Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) provides $849,969 to the University of Cincinnati to investigate the interplay between the allosteric properties of microtubule lattices and protein-protein interactions that impact neuronal function. The project aims to use multi-scale computational modeling and machine learning, complemented by experimental testing, to provide quantitative insight into how changes in tubulin subunits induced by microtubule-associated protein (MAP) binding influence the function of molecules designed to enhance or block that MAP binding. This research will address critical gaps in understanding the dynamic properties of microtubules and MAP-microtubule complexes in healthy and disease states, with the potential to inform the development of treatments for neurological disorders like Alzheimer's disease and cancer. The award includes providing education and training for undergraduate and graduate students in computational biophysical chemistry and machine learning.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $850.0k | 7/28/25 |