Project Grant R01GM164613
- Federal Grant Award Summary The University of Colorado Boulder received a $495,480 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded April 3, 2026, with completion targeted for December 31, 2030. Under this Maximizing Investigators' Research Award (MIRA), Dr. Deborah Wuttke's laboratory will conduct fundamental research investigating regulatory nucleic acid interactions and telomere...
- This National Science Foundation award provides $1,656,474 to the University of Colorado Boulder through May 2026 to develop mathematical models of mitosis under the Biological Sciences grant program (CFDA 47.074). The university will build on previous work modeling chromosome segregation during cell division to create a new model integrating deformable nuclear envelope dynamics. Researchers aim to identify how forces within the nuclear envelope drive successful chromosome separation during...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded $760,140 to the University of California, San Francisco under the Biomedical Research and Research Training program (CFDA 93.859) for a project grant titled "Active Chromosome Movement in Meiotic Pairing." The award, effective July 1, 2025, through March 31, 2029, supports fundamental research investigating the cellular mechanisms underlying homologous chromosome pairing during meiosis—a...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded University of Colorado-Denver a $1,998,288 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) effective September 1, 2025, through August 31, 2029. The award funds investigator-initiated research to develop and apply Co-Translational Folding Tracking (COTFT), a novel technology platform designed to visualize and quantify protein co-translational folding...
- Federal Grant Award Summary The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $1,493,073 Project Grant to the University of Colorado, effective June 15, 2026 through May 31, 2030, under the Biological Sciences program (CFDA 47.074). This collaborative research project investigates the regulation of RNA polymerase II (RNAPII) transcription at gene 3-ends by CDK7 kinase, a critical enzyme involved in genome decoding and cellular function. The primary...
- This three-year $484,222 project grant from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) supports collaborative research at the University of Colorado Boulder to develop a mesoscale kinetic theory framework for early mitotic spindle organization. The research team will combine biophysical experiments, computational modeling, and statistical analysis to build understanding of how spindle formation is affected by interactions between diverse protein...
- The University of Colorado has been awarded $404,490 by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) for a five-year Project Grant effective September 1, 2025, through August 31, 2030. This award supports the development of computational tools and systematically improvable force fields for molecular simulation in pharmaceutical drug design. The research addresses current limitations in modeling protein-ligand...
- Federal Project Grant Award Summary The University of Minnesota's Office of Sponsored Projects Administration received a $404,058 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025 through June 30, 2030. This award supports fundamental biomedical research investigating single-molecule imaging and the mechanisms of crossover regulation on meiotic chromosomes. The...
- Federal Project Grant Award Summary The University of California, San Diego received a $479,738 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective May 1, 2026 through April 30, 2031. This research project advances fundamental understanding of kinetochore machinery and chromosome segregation during cell division. The primary deliverable is original scientific research...
- Federal Project Grant Award Summary The University of Colorado received a $238,819 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective August 1, 2025, through July 31, 2028. The award funds fundamental research investigating the regulation of zinc-dependent lysosome morphological restructuring, zinc trafficking, and low zinc homeostasis mechanisms across Caenorhabditis elegans...
Federal Project Grant Award Summary The University of Colorado at Boulder received a $426,262 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective July 1, 2026, through March 31, 2030. This award funds computational modeling and experimental research to elucidate the mechanisms controlling mitotic spindle length, stability, and elongation during closed mitosis. The project addresses fundamental gaps in understanding how physical forces and biochemical regulation interact to govern chromosome segregation, with particular emphasis on the role of nuclear envelope remodeling and its mechanical coupling to spindle dynamics. The research will deliver two primary products: (1) mechanistic insights into force and biochemistry regulation of metaphase spindle maintenance through computational modeling and measurement studies, and (2) mechanistic understanding of spindle elongation during anaphase B. By utilizing the fission yeast system as a genetically tractable model organism, the project will generate foundational knowledge of cytoskeleton-nucleus coupling applicable to broader cellular processes including organelle remodeling and cellular compartmentalization. The computational modeling framework developed through this award will advance the field's capacity to predict spindle behavior under varying physical and molecular constraints.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $426.3k | 6/1/26 |