Project Grant 2521597
- This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program provides $200,000 in funding to The Trustees of the University of Pennsylvania to conduct collaborative research that aims to understand genomic organization in the cell nucleus. The research team will employ an integrated approach leveraging biophysical modeling, super-resolution imaging, and machine learning to develop predictive models of how chromatin structure and...
- This Project Grant award from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) provides $200,000 to The Johns Hopkins University to conduct research on "Defining Barriers to Nucleosome Mobility Through Single-Molecule Manipulation". The research aims to understand how nucleosomes, the DNA-protein structures that package chromosomes, can spontaneously slide along DNA and be actively moved by cellular enzymes called chromatin remodelers. This...
- This National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems Project Grant of $500,000 awarded to Beth Israel Deaconess Medical Center, Inc. (Bidmc) aims to develop a novel, label-free method for dynamically sensing chromatin packing and structure in live cells. The 3-year project leverages the principles of fractal sensing and coherent confocal light absorption and scattering spectroscopic microscopy to create a 3D dynamic map of chromatin...
- This $1,220,400 Project Grant awarded by the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences supports a collaborative research project between investigators in the U.S. and U.K. to better understand the regulatory mechanisms controlling mammalian gene expression. The project, funded through NSF's Biological Sciences program (CFDA 47.074), aims to define the roles of different DNA regulatory elements and how they work together to precisely control gene expression....
- The National Science Foundation awarded a $501,269 Project Grant to Stanford University under the Mathematical and Physical Sciences program (CFDA 47.049). The grant will fund theoretical and computational modeling of supercoiling, topology, and active fluctuations in chromosomal organization and dynamics from September 2021 through August 2024. As part of the Mathematical and Physical Sciences program's goal of strengthening the Nation's scientific enterprise through increased understanding...
- This four-year, $1.388 million project grant from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) supports collaborative research between New York University and other organizations to discover the principles of active self-organization in the differentiating genome. The research will integrate state-of-the-art live cell experiments with multiscale mathematical and computational models of chromatin dynamics in the cell nucleus. Experiments will...
- This federal Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $374,999 to the University of California, San Diego to conduct collaborative research on the biological mechanisms underlying analog information storage in chromatin state. The research aims to investigate how gene expression can be locked at a range of levels, rather than just binary "on" or "off" states, which could enable new applications in tissue...
- This federal Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $776,309 to The Pennsylvania State University to conduct research on the structural responses of intrinsically disordered proteins to chemical modifications that regulate gene expression. The project aims to develop new experimental methodology for nuclear magnetic resonance (NMR) spectroscopy to gain quantitative insights into these regulatory mechanisms. The research...
- This federal Project Grant award of $899,982 from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports a collaborative research effort to study X-chromosome inactivation and genome organization in human cells. The research team from New York University, Harvard University, and the New Mexico Consortium will integrate advanced genomics data, computational modeling, and biophysical approaches to unravel the complex folding of the X-chromosome and its impact on...
- The Regents of the University of California, San Francisco (UCSF) received a $1,242,532 Project Grant award from the National Science Foundation Division of Molecular and Cellular Biosciences on June 15, 2021 to fund research through May 31, 2025. The grant supports research to define how transcriptionally active euchromatin and repressive heterochromatin domains are maintained over multiple cell generations. Specifically, the University of California, San Francisco will investigate how the...
The National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) awarded a $1,000,000 Project Grant to The Pennsylvania State University to investigate the 3-dimensional structural motifs and molecular mechanisms that direct the folding of chromatin into euchromatin (open, active) and heterochromatin (repressed, condensed) states. This 3-year project will employ cryo-electron tomography to determine the chromatin structures and nucleosome array folding associated with euchromatin and heterochromatin compartments in human and mouse cells. The goal is to reveal how the natural nucleosome spacing distribution governs differential chromatin folding and associated genetic functions, which is crucial for understanding gene expression, cell differentiation, chromosomal stability, and genetic abnormalities. The research will be integrated with postdoctoral training and graduate/undergraduate STEM education to inspire student enthusiasm for scientific discoveries.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 7/29/25 | ||
| Not listed | $1.0m | 7/29/25 |