The Regents of the University of California, San Francisco (UCSF) received a $284,636 Project Grant award from the National Science Foundation Division of Molecular and Cellular Biosciences under the Biological Sciences (CFDA 47.074) federal grant program. The two-year award will support research establishing novel tools to artificially manipulate chromosome folding and modulate various genome functions, including enhancer regulation of gene expression. Specifically, the grant will fund...
The University of California, San Diego received a $300,000 Project Grant award from the National Science Foundation on February 1, 2021 to develop a high-throughput in vivo method for measuring transcription factor-DNA interactions. The grant supports research under the NSF's Biological Sciences program (CFDA 47.074) through January 31, 2023. The Biological Sciences program aims to advance the fundamental biological sciences and enhance understanding of major problems through basic research....
The National Science Foundation awarded a two-year $299,986 Project Grant to the University of California, Davis under the Biological Sciences federal grant program (CFDA 47.074) from June 2023 to May 2025. The grant will support development of a new method to measure genome-wide targeting of histone readers, proteins that bind histone modifications to translate epigenetic codes into biological processes. If successful, the tool could help decipher how histones orchestrate genome and organism...
The National Science Foundation awarded a $1,715,342 project grant to The Regents of the University of California, San Francisco under the Biological Sciences program (CFDA 47.074) to elucidate the mechanisms that regulate nuclear size in cells. Over three years from August 2022 through July 2025, the researchers will develop a quantitative model proposing that nuclear size is specified by physical factors such as osmotic pressure and membrane tension. They will test this osmotic model of...
This federal Project Grant award, valued at $380,070.00 and effective from July 1, 2025 to March 31, 2029, was issued by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award supports research conducted by The Regents of the University of California, San Francisco (UCSF) to investigate the cellular mechanisms of meiotic chromosome pairing, including the role of telomere-led active motion and nuclear...
The Regents of the University of California at Riverside received a $1.56M Project Grant award from the National Science Foundation Division of Integrative Organismal Systems. The award is part of the NSF's Biological Sciences program (CFDA 47.074) and will fund research from September 2021 through August 2025 to decipher the robustness mechanisms of the stem promoting transcription factor gradient. The Biological Sciences program aims to advance the field and strengthen the national...
This Project Grant award, valued at $775,170, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training (CFDA 93.859) program. The funding supports research by the University of California, San Diego (UCSD) to investigate the organization and function of regulatory DNA, which controls gene expression patterns during development and in response to stimuli. Using experimental and computational approaches, the research aims to...
This Project Grant award of $254,919 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training (CFDA 93.859) federal grant program, aims to advance the understanding of regulatory mechanisms that ensure accurate transmission of the genome during cell division. The key focus areas are: 1) Investigating how cells regulate the loading and removal of the Mini-Chromosome Maintenance (MCM) complex to prevent incomplete DNA replication, a major...
This National Science Foundation project grant of $1,011,518 supports collaborative research between the University of California, San Diego and the State of California Controller's Office to discover the principles of active self-organization in the differentiating genome. The award period is from July 1, 2022 through June 30, 2026 under the Mathematical and Physical Sciences program (CFDA 47.049). The project will integrate state-of-the-art live cell experiments with multiscale mathematical...
This $1,220,400 Project Grant awarded by the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences supports a collaborative research project between investigators in the U.S. and U.K. to better understand the regulatory mechanisms controlling mammalian gene expression. The project, funded through NSF's Biological Sciences program (CFDA 47.074), aims to define the roles of different DNA regulatory elements and how they work together to precisely control gene expression....