Project Grant 2337392

This Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $899,982 in funding to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), for a collaborative research project on understanding X-chromosome inactivation and genome organization in human cells. The multidisciplinary research team from NYU, Harvard, and the New Mexico Consortium will integrate advanced experimental genomics data with computational modeling to elucidate the complex folding of DNA into chromosomes and its impact on gene expression. The project aims to deepen the understanding of X-chromosome inactivation, a fundamental biological process with significant health implications. The research will also offer interdisciplinary training opportunities for young scientists and public outreach through a museum exhibit. This award reflects the NSF's mission to support fundamental scientific discovery and enable innovative approaches to address complex biological challenges.