This National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) $776,309 federal grant award to The Pennsylvania State University, doing business as Penn State, will support research to investigate the structural responses to chemical modifications that trigger release from pausing and entry into efficient decoding of genetic information by RNA polymerase II. The 3-year project, with a start date of February 15, 2025, will push the boundaries of current nuclear magnetic resonance (NMR) spectroscopy techniques to characterize how phosphorylation and methylation of RNA polymerase II and its regulatory co-factors impact the enzyme's function and gene expression regulation. The research aims to yield fundamental, molecular-level insights into this critical gene regulatory mechanism.
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