Project Grant 2530651
- The National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) awarded a $1,000,000 Project Grant to The Pennsylvania State University to investigate the 3-dimensional structural motifs and molecular mechanisms that direct the folding of chromatin into euchromatin (open, active) and heterochromatin (repressed, condensed) states. This 3-year project will employ cryo-electron tomography to determine the chromatin structures and nucleosome array folding associated with...
- This $363,800 Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research by The Johns Hopkins University investigating how supercoiled DNA impacts transcription, a core process of life that converts genetic information into RNA. The research will: Characterize how supercoiling affects transcription kinetics and correlation using in vitro single-molecule imaging of purified proteins and DNA constructs. Determine how chromosomal...
- This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program provides $200,000 in funding to The Trustees of the University of Pennsylvania to conduct collaborative research that aims to understand genomic organization in the cell nucleus. The research team will employ an integrated approach leveraging biophysical modeling, super-resolution imaging, and machine learning to develop predictive models of how chromatin structure and...
- This four-year, $1.388 million project grant from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) supports collaborative research between New York University and other organizations to discover the principles of active self-organization in the differentiating genome. The research will integrate state-of-the-art live cell experiments with multiscale mathematical and computational models of chromatin dynamics in the cell nucleus. Experiments will...
- The National Science Foundation awarded a $501,269 Project Grant to Stanford University under the Mathematical and Physical Sciences program (CFDA 47.049). The grant will fund theoretical and computational modeling of supercoiling, topology, and active fluctuations in chromosomal organization and dynamics from September 2021 through August 2024. As part of the Mathematical and Physical Sciences program's goal of strengthening the Nation's scientific enterprise through increased understanding...
- The Board of Regents of the University of Nebraska received a $649,999 Project Grant award from the National Science Foundation Division of Molecular and Cellular Biosciences on August 15, 2021 to support research titled "Nanoscale Structure and Dynamics of Nucleosome Arrays Assembled on DNA Templates with Physiologically Relevant Sequences." The award is part of the NSF's Biological Sciences program (CFDA #47.074), which aims to promote progress in the biological sciences and...
- This National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems Project Grant of $500,000 awarded to Beth Israel Deaconess Medical Center, Inc. (Bidmc) aims to develop a novel, label-free method for dynamically sensing chromatin packing and structure in live cells. The 3-year project leverages the principles of fractal sensing and coherent confocal light absorption and scattering spectroscopic microscopy to create a 3D dynamic map of chromatin...
- This Project Grant award of $550,000 from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports research at Iowa State University to investigate how different histone writer enzymes coordinate to regulate gene expression and chromatin structure. The project will explore how the histone modifications H3K9me2, H3S10ph, and H4K16ac work together to fine-tune gene expression levels by controlling chromatin accessibility. Experiments will utilize Drosophila larval...
- The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $669,456 Project Grant to the University of Chicago under the Biological Sciences program (CFDA 47.074) for the project "Collaborative Research: Tools 4 Cells: Developing Next Generation Methods for Studying Cytoskeletal Factors in the Cell Nucleus". This 3-year project aims to develop novel tools to precisely perturb and study the role of the cytoskeletal protein actin within the cell...
- This Project Grant, awarded by the National Science Foundation's Biological Sciences program (CFDA 47.074), provides $900,000 in funding to The Regents of the University of Colorado from February 1, 2025 to January 31, 2028. The project focuses on uncovering the molecular mechanisms by which the DNA methyltransferase 1 (DNMT1) enzyme regulates gene silencing and the inheritance of distinct cell identities. The research will utilize structural biology, biochemistry, and cell biology methods to...
This Project Grant award from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) provides $200,000 to The Johns Hopkins University to conduct research on "Defining Barriers to Nucleosome Mobility Through Single-Molecule Manipulation". The research aims to understand how nucleosomes, the DNA-protein structures that package chromosomes, can spontaneously slide along DNA and be actively moved by cellular enzymes called chromatin remodelers. This work will investigate how DNA sequence, histone variants, and other cellular factors affect the intrinsic mobility of nucleosomes, as well as determine the speed and processivity of chromatin remodelers as they shift nucleosomes. The project will train students in biochemical and biophysical research techniques and include outreach activities to engage middle school students in STEM topics related to DNA. This research is expected to advance the fundamental understanding of how chromosome packaging is dynamically regulated, which has implications for human health conditions like cancer where nucleosome displacement and chromatin remodeling are often disrupted.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $200.0k | 8/14/25 |