This $1,200,000 Project Grant award from the National Science Foundation's Biological Sciences program supports research at the University of Illinois to elucidate the role of peptidyl-tRNA hydrolase (PTH) enzymes in bacterial protein synthesis quality control mechanisms. The 4-year project aims to use ribosome profiling and structural biology approaches to identify where PTH rescues stalled ribosomes and understand the underlying mechanistic principles. The research findings are expected to advance scientific understanding of protein synthesis quality control strategies, which may guide future efforts to develop new antibiotics and treatments for diseases associated with defective protein translation. The project will also incorporate educational components to train high school, college, graduate, and postdoctoral students in the research activities.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $1.2m | 2/12/24 |