Project Grant 2420238
Award Date
8/1/24
Completion Date
7/31/27
Dollars Obligated
$1M
Federal Agency
Division of Molecular and Cellular Biosciences
Federal Grant Program
47.074
Assistance Type
Project Grant
Place of Performance
Albany, CA 94710, USA
Similar Awards
The National Science Foundation (NSF) awarded a $1,000,000 Project Grant under the Biological Sciences (CFDA 47.074) program to The Regents of the University of California, San Francisco (UCSF) to design, build, and test synthetic signaling systems built from computationally designed de novo protein components. The goal is to develop synthetic membrane signaling systems capable of programmable receptor clustering, tunable signal amplification, and bidirectional transmembrane signaling. This...
The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences and the Division of Chemical, Bioengineering, Environmental and Transport Systems awarded a $240,000 Project Grant to the University of California Irvine (UC Irvine) under the NSF Biological Sciences program (CFDA 47.074). The grant supports collaborative research to develop unnatural cofactors that can be deployed as stronger-than-nature thermodynamic driving forces in biomanufacturing processes. This is...
This $369,297 Project Grant award from the National Science Foundation (NSF) Biological Sciences (CFDA 47.074) program supports research at San Francisco State University to develop a synthetic transhydrogenation module to enhance biosynthesis of valuable chemicals.
The key objectives are to: 1) elucidate the structural mechanisms underlying autoregulation of the GltAB-GudB enzyme complex in Bacillus subtilis, which regulates glutamate metabolism, 2) leverage this understanding to engineer...
This $300,000 Project Grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports collaborative research at the University of Texas at Austin to develop synthetic cells with expanded genetic alphabets and genetic codes. The key objectives are to:
Investigate the incorporation of non-canonical nucleotides into protein translation systems (Aim 1),
Incorporate non-canonical amino acids using non-canonical genetic alphabets (Aim 2), and
Use...
This $1,120,000 Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) aims to explore the boundaries of life's genetic alphabet beyond the natural 4-letter system (A, T, G, C). The research will develop model systems to study the biomolecular properties of a 6-letter genetic alphabet (A, T, G, C, P, Z) and map critical interactions necessary for translation of this expanded genetic code. The project will use synthetic biology and chemical...
This National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) Project Grant award of $170,000 supports collaborative research between the Ellington and Adamala labs to engineer synthetic cells with expanded genetic alphabets and genetic codes. The key products and services to be delivered under this 3-year grant include:
Investigating the incorporation of non-canonical nucleotides into translation (Aim 1)
Incorporating non-canonical amino acids via non-canonical genetic...
The National Science Foundation awarded a $138,000 Project Grant to support research titled "Understanding Protein Synthesis in Energetically Constrained Microbial Consortia" from September 1, 2021 through August 31, 2023. The grant was awarded under the Biological Sciences program (CFDA 47.074) to further the program's goals of advancing the biological sciences and strengthening the scientific enterprise through increased knowledge and understanding of major issues facing the...
The National Science Foundation (NSF) awarded a $740,797 Project Grant under the Biological Sciences federal grant program (CFDA 47.074) to the Regents of the University of California, San Francisco (UCSF) to develop and test new methodologies for the rational design of minimalistic light-switchable single-domain proteins. The goal is to engineer these proteins to bind specifically to target proteins in only one photoswitchable chromophore state, allowing for precise spatial and temporal...
The National Science Foundation (NSF) awarded a $400,546 Project Grant under the Biological Sciences program (CFDA 47.074) to the University of California Irvine (UC Irvine) to support research aimed at using a rapid gene evolution system to transform simple artificial catalysts into advanced biological enzymes.
The key objectives of this 4-year project are to: 1) Understand how enzymes can upgrade their performance over long evolutionary timescales, 2) Provide blueprints for enzyme design,...
The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $590,000 Project Grant to the University of California Irvine (UC Irvine) on August 15, 2023 under the Biological Sciences program (CFDA 47.074). The goal of this 3-year research project is to develop novel strategies for real-time metabolite sensing and metabolite-induced enzyme localization that can contribute to fundamental cellular knowledge and improve the efficiency of synthetic biology...