This federal Project Grant award, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), is focused on exploring post-transcriptional regulators in the bacterial pathogen Acinetobacter baumannii. The $388,750 award, which runs from January 1, 2025 to November 30, 2029, will support research aimed at systematically dissecting RNA-RNA interactions mediated by the RNA-binding protein Hfq and further...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $479,924 to The Pennsylvania State University (Penn State) to study how RNA structure regulates gene expression in Escherichia coli and Bacillus subtilis. The research aims to determine the mechanisms by which RNA polymerase pausing and transcription termination are controlled by the transcription elongation factors...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training (CFDA 93.859) program, will support work on computational methods for gene finding to improve human gene annotation. The total funding amount is $387,500.00, with a project period from January 1, 2025 to November 30, 2029. The awardee, The Johns Hopkins University, will focus on developing efficient algorithms to process and summarize large-scale RNA...
This federal Project Grant award of $1,612,448 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award will support a research project at the University of Chicago to develop computational methods and analytical frameworks to study the mechanisms and functions of mRNA splicing. Specifically, the project aims to (i) develop computational tools to facilitate studies of RNA splicing in human...
This Project Grant award, valued at $433,459, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training (CFDA 93.859) federal grant program. The award supports research to expand the understanding of quorum sensing, which is a type of cell-cell communication used by bacteria to coordinate group activities. The overarching goal is to combine laboratory models with molecular genetic and genomic approaches to study how quorum...
This National Science Foundation (NSF) Project Grant award under the Biological Sciences (CFDA 47.074) program provides $698,693 to The Johns Hopkins University to develop innovative computational methods for large-scale transcriptome profiling. The project aims to advance the state-of-the-art in analyzing RNA sequencing data by creating cutting-edge software to address challenges in transcriptome assembly and gene annotation. Key focus areas include developing a scalable approach for assembling...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training (CFDA 93.859) program, provides $658,165 to Triad National Security, LLC to conduct advanced research on the effects of ions on mRNA elements, ribosomes, and antibiotic-RNA interactions. The research aims to gain a better understanding of the fundamental physics underlying ribosome operation and mRNA regulation, with a focus on the bacterial ribosome and...
This federal Project Grant award of $651,596 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research by the Cold Spring Harbor Laboratory (CSHL) to study the molecular mechanisms that coordinate gene expression, cell fate determination, and tissue growth during development. The key research objectives are to: 1) Determine the molecular structures and dynamics of three transcriptional complexes that regulate...
This federal Project Grant award from the National Institute of General Medical Sciences (CFDA 93.859 - Biomedical Research and Research Training) provides $406,250.00 to The Trustees of the University of Pennsylvania over a 5-year period from August 15, 2024 to July 31, 2029. The research focuses on mapping the post-transcriptional aspects of gene expression, with a specific emphasis on understanding alternative ribosome initiation and the role of RNA modifications and binding proteins in...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $440,000.00 in funding to the University of Texas Medical Branch at Galveston (UTMB) to conduct research on two key areas: Characterizing the mechanisms by which contractile injection systems, such as phage tails and tailocins, breach bacterial cell envelopes. This knowledge will inform the design and retargeting of R-type...
This Project Grant award of $1,891,854.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training (CFDA 93.859) Federal Grant Program, will support research at Howard University to expand the understanding of post-transcriptional regulation of gene expression in bacteria.
The two-part research program will: 1) investigate epitranscriptomic regulation of gene expression across a range of bacterial species using a multi-omics approach, and 2) explore the regulatory role of novel proteins and small RNAs in post-transcriptional gene regulation in Firmicute bacteria. The research aims to address key knowledge gaps in these areas and leverage Howard University's expertise in bacterial molecular biology and genetics. The award has an initial project period from Aug 2, 2024 to May 31, 2029.