Project Grant 2205665
- The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $206,912 Project Grant under the Biological Sciences (CFDA 47.074) program to the University of North Carolina at Chapel Hill. The three-year grant, effective August 1, 2023 through July 31, 2026, supports collaborative research to enhance the understanding of protein structures and behaviors at extreme temperature and pressure conditions. The research aims to develop rules for predicting protein...
- This award from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $741,000 to the University of Chicago to develop a fast and accurate computational tool called UPSIDE for simulating the dynamics and structure of large membrane proteins involved in sensing environmental stimuli like force and heat. The research aims to enhance the understanding of how sensory membrane proteins in humans and animals function at the atomic level, which is crucial for addressing...
- The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $710,128 Project Grant under the Biological Sciences (CFDA 47.074) program to The Research Foundation For The State University Of New York (SUNY) to conduct collaborative research on the "Energy Landscapes of Designed Cold Unfolding Proteins." The research aims to enhance understanding of the distinct three-dimensional shapes that proteins can adopt at extreme cold temperatures and high...
- The National Science Foundation Division of Molecular and Cellular Biosciences awarded a $199,511 Project Grant to the University of Illinois to support research titled "COLLABORATIVE RESEARCH: UNDERSTANDING PROTEIN MECHANICAL STABILITY AND ITS IMPACT ON SECRETION" from January 15, 2022 through December 31, 2024. The grant funds basic research under the Biological Sciences program (CFDA 47.074), which aims to promote advancement in the biological sciences and strengthen the nation's...
- This National Science Foundation (NSF) Project Grant award under the Biological Sciences program (CFDA 47.074) provides $270,000.00 over a 3-year period from July 1, 2025 to June 30, 2028. The award funds a postdoctoral fellowship to investigate the evolutionary determinants of protein biophysics and their implications for modeling, predicting, and directing evolutionary trajectories. The research will examine the relationship between protein thermodynamic stability and effective population...
- The University of Chicago received a $358,830 Project Grant award from the National Science Foundation (NSF) Division of Integrative Organismal Systems under the Biological Sciences program (CFDA 47.074), effective September 1, 2025 through August 31, 2028. This award supports fundamental research investigating the evolution and mechanisms of thermotolerance in cyanobacteria, with the primary deliverables including scientific data on genomic features that predict optimal growth temperature,...
- This $100,000 Project Grant awarded by the National Science Foundation's Biological Sciences program (CFDA 47.074) will support the development of deep-learning models, specifically consistency models, to simulate the long-time-scale dynamics of protein structures. The project aims to address the limitations of current molecular dynamics (MD) simulations in capturing crucial long-duration protein dynamics events, such as protein folding and aggregation. By developing these advanced computational...
- The National Science Foundation (NSF) awarded a $253,890 Project Grant under the Biological Sciences program (CFDA 47.074) to Western University of Health Sciences to conduct research on sensory membrane proteins. The goal is to develop computational tools capable of realistic simulations of how these proteins respond to external stimuli like pressure, heat, and sound. The research project, titled "Collaborative Research: Ultra-Fast Simulations of Sensory Membrane Proteins with Validation...
- This $100,000 Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) will fund a collaborative research project to develop deep-learning models, specifically consistency models, to simulate protein dynamics more efficiently and over longer time scales. The goal is to address the limitations of current molecular dynamics (MD) simulations in capturing the long-time-scale dynamics of protein structures, which are essential for understanding processes...
- This Project Grant award from the National Science Foundation's Biological Sciences (CFDA 47.074) program provides $410,939 to Clemson University to conduct research on the biophysical mechanisms of membrane protein folding and stability. The project will use advanced single-molecule force spectroscopy techniques, specifically atomic force microscopy, to study how membrane proteins interact with cell membranes and maintain their proper structure. The goal is to gain fundamental biophysical...
This $795,135 Project Grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research at the University of Illinois on protein dynamics under extreme environmental conditions. The four-year award beginning June 1, 2022 will fund three related subprojects investigating how proteins adapt to enable organism survival in stressful environments like heat, pressure and dehydration. The research will study intrinsically disordered protein structure and interactions under cellular crowding, analyze heat shock chaperone functions across zebrafish tissues, and examine how extremophile enzymes tune native state fluctuations to function over wide temperature and pressure ranges. Results aim to further understanding of protein evolution, flexibility, novel structure and function, and tissue-specific adaptation. The award also supports training of researchers from high school through postgraduate levels on techniques for solving problems involving extreme environmental scenarios.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $795.1k | 5/19/22 |