The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $750,000 Project Grant titled "TRANSITIONS: EVOLVING OUR UNDERSTANDING OF DYNAMIC RNA FOLDING AND FUNCTION" to Northwestern University under the Biological Sciences grant program (CFDA 47.074). The objective of this 3-year award is to uncover fundamental principles linking RNA sequence to dynamic RNA folding processes and function in biological systems. The research aims to enhance the...
The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $590,000 Project Grant to the University of California Irvine (UC Irvine) on August 15, 2023 under the Biological Sciences program (CFDA 47.074). The goal of this 3-year research project is to develop novel strategies for real-time metabolite sensing and metabolite-induced enzyme localization that can contribute to fundamental cellular knowledge and improve the efficiency of synthetic biology...
The National Science Foundation Division of Molecular and Cellular Biosciences awarded a $199,511 Project Grant to the University of Illinois to support research titled "COLLABORATIVE RESEARCH: UNDERSTANDING PROTEIN MECHANICAL STABILITY AND ITS IMPACT ON SECRETION" from January 15, 2022 through December 31, 2024. The grant funds basic research under the Biological Sciences program (CFDA 47.074), which aims to promote advancement in the biological sciences and strengthen the nation's...
This $300,000 Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences will support research into the structural biology of RNA and RNA-protein interactions through May 2024. Funded under the Biological Sciences program (CFDA 47.074), this award to Vanderbilt University will utilize joint cryo neutron/x-ray crystallography techniques to better understand the importance of the 2'-hydroxyl group in RNA's expanded three-dimensional structure compared to DNA....
The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $949,953 Project Grant to the Research Foundation Of The City University Of New York, doing business as Rfcuny - Hunter College, from August 1, 2023 to July 31, 2026. The grant, funded under the Biological Sciences program (CFDA 47.074), will support research to identify molecular interactions and build a detailed model of translational regulation, specifically examining the role of eIF3 and 4E-BP in...
The National Science Foundation (NSF) awarded a $1,199,997 Project Grant under its Biological Sciences program (CFDA 47.074) to the University of Colorado-Denver. The grant will fund research to improve understanding of the mechanisms underlying messenger RNA (mRNA) localization and translation, and develop machine learning models to better predict protein production from mRNA. The project will apply recent advancements in RNA sequencing technology to study how factors like tRNA abundance and...
This $795,135 Project Grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research at the University of Illinois on protein dynamics under extreme environmental conditions. The four-year award beginning June 1, 2022 will fund three related subprojects investigating how proteins adapt to enable organism survival in stressful environments like heat, pressure and dehydration. The research will study intrinsically disordered protein structure and...
This Project Grant award from the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences, under the Biological Sciences CFDA program (47.074), will investigate a novel regulatory mechanism called "RNA buffering" that maintains messenger RNA (mRNA) levels despite changes in synthesis and decay rates. The $749,978 project at the University of Utah will explore the protein-protein and protein-RNA interactions involved in this process, which challenges...
The University of Utah will receive $492,516 from the National Science Foundation Division of Molecular and Cellular Biosciences under a three-year Project Grant award titled "Role of Electric Fields and a Dynamic Local Environment in Protein-RNA Molecular Recognition." The grant funds basic research from August 1, 2021 to July 31, 2024 to advance understanding of major problems in the biological sciences by investigating the role of electric fields and the local molecular...
This $299,999 National Science Foundation project grant under the Biological Sciences program (CFDA 47.074) will support research exploring the RNA world and RNA-peptide world hypotheses using a novel dynamic combinatorial chemistry system at the University of Houston, a minority-serving institution. The two-year project beginning August 1, 2022 aims to advance understanding of the role of RNA and peptides in the origins of life. Investigators will employ a system using benzonuclease to cleave...