Project Grant 2345648

Award Date 6/15/24
Completion Date 5/31/28
Dollars Obligated $543K
Federal Grant Program
47.041
Assistance Type
Project Grant
Place of Performance
Chicago, IL 60612, USA
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This $543,105 federal Project Grant awarded by the National Science Foundation (NSF) under its Engineering program (CFDA 47.041) aims to investigate an approach for creating an optimized ribosome system to efficiently produce designer proteins.

The key objective is to construct a ribosome that is hardwired to synthesize a specific protein by incorporating the genetic message directly into the ribosome structure. This "iRibo-T" system is expected to isolate the ribosome from normal cellular translation, allowing for the optimization of production for medically and industrially relevant polylysine-containing proteins that are problematic for unmodified bacterial ribosomes. The project will involve undergraduate and high school students participating in summer research activities to support this grant. The award has an ultimate completion date of May 31, 2028.

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