Project Grant 2313792
- The Regents of the University of California, San Francisco (UCSF) received a $1,242,532 Project Grant award from the National Science Foundation Division of Molecular and Cellular Biosciences on June 15, 2021 to fund research through May 31, 2025. The grant supports research to define how transcriptionally active euchromatin and repressive heterochromatin domains are maintained over multiple cell generations. Specifically, the University of California, San Francisco will investigate how the...
- This federal Project Grant award of $380,070.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports a research project titled "ACTIVE CHROMOSOME MOVEMENT IN MEIOTIC PAIRING" at the University of California, San Francisco (UCSF). The project aims to investigate the cellular mechanism of meiotic pairing, testing hypotheses regarding the role of telomere-led active motion and nuclear...
- This federal Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $374,999 to the University of California, San Diego to conduct collaborative research on the biological mechanisms underlying analog information storage in chromatin state. The research aims to investigate how gene expression can be locked at a range of levels, rather than just binary "on" or "off" states, which could enable new applications in tissue...
- This $1,220,400 Project Grant awarded by the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences supports a collaborative research project between investigators in the U.S. and U.K. to better understand the regulatory mechanisms controlling mammalian gene expression. The project, funded through NSF's Biological Sciences program (CFDA 47.074), aims to define the roles of different DNA regulatory elements and how they work together to precisely control gene expression....
- The National Science Foundation awarded a two-year $299,986 Project Grant to the University of California, Davis under the Biological Sciences federal grant program (CFDA 47.074) from June 2023 to May 2025. The grant will support development of a new method to measure genome-wide targeting of histone readers, proteins that bind histone modifications to translate epigenetic codes into biological processes. If successful, the tool could help decipher how histones orchestrate genome and organism...
- The University of California, San Diego received a $300,000 Project Grant award from the National Science Foundation on February 1, 2021 to develop a high-throughput in vivo method for measuring transcription factor-DNA interactions. The grant supports research under the NSF's Biological Sciences program (CFDA 47.074) through January 31, 2023. The Biological Sciences program aims to advance the fundamental biological sciences and enhance understanding of major problems through basic research....
- This federal Project Grant award of $135,206 from the National Human Genome Research Institute (NHGRI), under the Human Genome Research Federal Grant Program (CFDA 93.172), supports the development of two novel single-cell functional genomic technologies to investigate the causal relationship between DNA methylation changes and gene expression in human diseases. The award recipient, The Regents of the University of California, San Francisco (UCSF), aims to: 1) Develop a single-cell version of...
- The National Science Foundation awarded a $538,838 Project Grant under the Biological Sciences federal grant program (CFDA 47.074) to The Regents of the University of California, San Francisco for research titled "Collaborative Research: Mapping Protein-Membrane Interactions from Molecules to Cell-Level Dynamics." The research will develop multiscale models to map how individual protein structures and compositions interact with and deform cell membranes at varying scales, from...
- The National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) awarded a $1,000,000 Project Grant to The Pennsylvania State University to investigate the 3-dimensional structural motifs and molecular mechanisms that direct the folding of chromatin into euchromatin (open, active) and heterochromatin (repressed, condensed) states. This 3-year project will employ cryo-electron tomography to determine the chromatin structures and nucleosome array folding associated with...
- The National Science Foundation awarded a $1,715,342 project grant to The Regents of the University of California, San Francisco under the Biological Sciences program (CFDA 47.074) to elucidate the mechanisms that regulate nuclear size in cells. Over three years from August 2022 through July 2025, the researchers will develop a quantitative model proposing that nuclear size is specified by physical factors such as osmotic pressure and membrane tension. They will test this osmotic model of...
The Regents of the University of California, San Francisco (UCSF) received a $284,636 Project Grant award from the National Science Foundation Division of Molecular and Cellular Biosciences under the Biological Sciences (CFDA 47.074) federal grant program. The two-year award will support research establishing novel tools to artificially manipulate chromosome folding and modulate various genome functions, including enhancer regulation of gene expression. Specifically, the grant will fund development of technologies using the cohesin protein complex to forcibly create or disable DNA looping at genomic locations, enabling re-folding of chromosomes. The resulting tools will be used to explore modulating, replacing, or bypassing enhancer regulation of genes, with potential applications in preventing cancer gene activation. Broader impacts include providing multi-disciplinary research training opportunities for students from diverse backgrounds. The award period is from June 1, 2023 to May 31, 2025.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $284.6k | 5/12/23 |