Project Grant K99HG014204
- This federal Project Grant award of $1,350,896, awarded on January 1, 2025 by the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172), supports the development of a multimodal massively parallel reporter assay (MPRA) platform to study regulatory sequence function. The overarching goal is to create tools that can elucidate the mechanisms and grammar by which regulatory elements in the genome encode interactions between chromatin, regulatory...
- This federal Project Grant award for $380,540.00, provided by the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 - Biomedical Research and Research Training, supports research to investigate the relationship between DNA methylation and microRNAs during early human embryonic stem cell lineage specification. The research program seeks to dissect the early cell fate changes due to epigenetic regulation using omics technologies, cell imaging, and transcriptional regulator...
- This Project Grant award from the National Human Genome Research Institute (NHGRI), under the Human Genome Research federal grant program (CFDA 93.172), provides $757,157 to the University of California, San Diego (UC San Diego) to develop complementary experimental and computational strategies for high-throughput characterization of the impact of genetic variants. The key objectives are to: 1) Develop a method called SCBE-SEQ that combines genome editing with single-cell sequencing to...
- This federal Project Grant award from the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172) provides $249,000.00 to the Regents of the University of California at Riverside to develop a novel "dual-barcoding" technology that utilizes laser particles with unique optical barcodes. This technology aims to enable the collection of live information on cells and connect that data to detailed omics information at the single-cell resolution....
- The National Human Genome Research Institute (NHGRI), under the Federal Grant Program for Human Genome Research (CFDA 93.172), awarded a $397,599 Project Grant to Xgenomes Corp. in Cambridge, MA. The grant supports the development of a novel epigenetic analysis method that can directly detect DNA methylation patterns across the genome with high accuracy, overcoming limitations of current sequencing techniques. The project aims to create advanced molecular analysis platforms that leverage machine...
- The National Human Genome Research Institute (NHGRI) awarded a $400,000 Project Grant (CFDA 93.172 - Human Genome Research) to the University of Washington to develop new single-cell multi-omic technologies for studying the relationship between three-dimensional genome organization and gene expression. Specifically, the grant will fund the development of CARE-Seq, a novel method to jointly measure whole-genome chromatin interactions and gene expression in the same single cells from complex...
- This Project Grant award from the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) will support the development of a one-year Master of Science (MS) program in Genomic Medicine for UCSF medical students. The $485,847 award, with a period of performance from September 2024 to August 2027, will fund the creation of innovative educational strategies and course content to train future physicians in the clinical applications of genetics and genomics. Key focus areas will...
- This $1,737,000 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports the development of innovative single-cell genomics technologies for joint analysis of regulatory dynamics and transcriptional states. Key objectives include: Developing multiomics tools to measure rates of epigenomic changes (DNA methylation, demethylation, oxidative damage, DNA repair) and relate these to...
- The Regents of the University of California, San Francisco (UCSF) received a $284,636 Project Grant award from the National Science Foundation Division of Molecular and Cellular Biosciences under the Biological Sciences (CFDA 47.074) federal grant program. The two-year award will support research establishing novel tools to artificially manipulate chromosome folding and modulate various genome functions, including enhancer regulation of gene expression. Specifically, the grant will fund...
- This $993,446 Project Grant award from the National Human Genome Research Institute (CFDA 93.172 Human Genome Research) supports the development of statistical and machine learning approaches to decode the regulatory activity underlying disease variants, link variants to genes in relevant cell types, and identify disease-critical cooperative programs of genes and genomic elements. The goal is to produce computational tools and workflows that can identify and rank functionally disease-critical...
This federal Project Grant award of $135,206 from the National Human Genome Research Institute (NHGRI), under the Human Genome Research Federal Grant Program (CFDA 93.172), supports the development of two novel single-cell functional genomic technologies to investigate the causal relationship between DNA methylation changes and gene expression in human diseases. The award recipient, The Regents of the University of California, San Francisco (UCSF), aims to: 1) Develop a single-cell version of the existing METHMPRA assay to quantify how DNA methylation affects gene regulatory activities in a cell-type specific manner; and 2) Establish a single-cell CRISPR-based methylation screening approach to assess the impact of disease-related methylation changes on gene expression. As a proof-of-concept, these single-cell assays will be applied to study cancer-associated methylation patterns. This research is expected to provide critical insights into the role of aberrant DNA methylation in human diseases.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $135.2k | 8/15/25 |