Project Grant 2213583

Award Date 8/1/22
Completion Date 7/31/25
Dollars Obligated $889K
Funding Federal Agency
National Science Foundation
Federal Grant Program
47.074
Assistance Type
Project Grant
Place of Performance
Waltham, MA 02453, USA
Similar Awards
The National Science Foundation awarded a $1,715,342 project grant to The Regents of the University of California, San Francisco under the Biological Sciences program (CFDA 47.074) to elucidate the mechanisms that regulate nuclear size in cells. Over three years from August 2022 through July 2025, the researchers will develop a quantitative model proposing that nuclear size is specified by physical factors such as osmotic pressure and membrane tension. They will test this osmotic model of...
Brandeis University was awarded a $299,944 project grant from the National Science Foundation Division of Molecular and Cellular Biosciences. The grant was awarded under the Biological Sciences program (CFDA 47.074) on November 1, 2021 for work to be completed by October 31, 2023. The grant will fund research into the repair and recombination of mitochondrial DNA. This work directly supports the goals of the Biological Sciences program to promote progress in the biological sciences and...
Brandeis University received a two-year, $299,751 Project Grant award from the National Science Foundation Division of Molecular and Cellular Biosciences to support the project "EAGER: CREATION AND VALIDATION OF A TOOL TO EXAMINE THE MOLECULAR MECHANISM OF REPLICATION FORK REPAIR." The grant's purpose aligns with the Biological Sciences program's goal to promote progress in the biological sciences and strengthen the Nation's scientific enterprise through increasing scientific knowledge...
This National Science Foundation award provides $1,656,474 to the University of Colorado Boulder through May 2026 to develop mathematical models of mitosis under the Biological Sciences grant program (CFDA 47.074). The university will build on previous work modeling chromosome segregation during cell division to create a new model integrating deformable nuclear envelope dynamics. Researchers aim to identify how forces within the nuclear envelope drive successful chromosome separation during...
This $395,749 federal Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) will enable researchers at Syracuse University to develop a comprehensive physics framework for understanding how cell nuclei and tissues adapt to extreme mechanical stress. The project aims to investigate the mechanisms by which cell nuclei deform and respond to compression, as well as how tissue-level forces impact chromatin organization. The...
This National Science Foundation Project Grant of $673,524 supports research at North Carolina State University to develop a mathematical model of mitosis through the Biological Sciences program (CFDA 47.074). The model will simulate chromosome segregation and nuclear envelope shape change coordination in fission yeast mitosis. Researchers will extend an existing mitosis model to include a deformable elastic nuclear envelope integrating the spindle, chromosomes, and nuclear envelope. They will...
The National Science Foundation awarded New York University a $120,000 Project Grant under the Mathematical and Physical Sciences federal grant program (CFDA 47.049) to develop a mathematical model of mitosis. The award period is from June 15, 2022 to May 31, 2026. Under the award, NYU will build on previous work modeling cell division to create a more realistic simulation of closed mitosis. Researchers will extend their model to include a deformable elastic nuclear envelope integrating the...
This Project Grant award of $229,840.00 from the National Science Foundation's Biological Sciences (CFDA 47.074) Federal Grant Program supports research at Brandeis University to investigate how a protein called HP1 helps cells maintain epigenetic memory. The project will use the fission yeast model organism to pursue three key objectives: (1) engineer synthetic H3K9me binding modules to test the influence of genome compartmentalization on epigenetic memory, (2) determine how...
This federal Project Grant award from the National Science Foundation's (NSF) Integrative Activities program (CFDA 47.083) supports research to quantify the mechanical forces inside living cells and determine how changes in these forces impact cellular behavior. The $160,000 award to Boise State University, with a project period from February 1, 2025 to January 31, 2028, aims to develop predictive tools that use mechanical forces to control cell behavior, enabling advances in tissue engineering,...
This two-year, $1,204,512 National Science Foundation project grant supports research into the robustness and adaptability of the dynamic epigenome through a multiscale approach. Funded under the Biological Sciences program (CFDA 47.074), the award to Brandeis University involves investigating the fundamental rules that guide adaptive epigenetic changes in cells without alterations to the genetic blueprint. The research utilizes high-resolution imaging, microfluidics, and automated culture...

Brandeis University was awarded an $889,060 project grant from the National Science Foundation (NSF) under the Biological Sciences program (CFDA 47.074) to elucidate the mechanisms that regulate nuclear size in cells. Over three years from August 2022 to July 2025, the researchers will develop a quantitative model proposing that nuclear size is specified by physical factors such as osmotic pressure and membrane tension. They will test this model through theoretical modeling combined with quantitative experiments in fission yeast, examining how physical parameters like osmotic pressure impact nuclear size and the mechanisms that couple nuclear growth to envelope surface area. Broader impacts include educational modules and an exhibit to introduce the importance of physical forces and quantitative measurements in cell biology research to the public.

Generated 1/6/24, 9:49 PM