This two-year, $1,204,512 National Science Foundation project grant supports research into the robustness and adaptability of the dynamic epigenome through a multiscale approach. Funded under the Biological Sciences program (CFDA 47.074), the award to Brandeis University involves investigating the fundamental rules that guide adaptive epigenetic changes in cells without alterations to the genetic blueprint. The research utilizes high-resolution imaging, microfluidics, and automated culture methods to study epigenetic processes across different time and length scales. It seeks to develop mathematical models predicting emergent properties of complex regulatory networks. Subawards of $275,000 and $150,000 to the University of Michigan and Boston University, respectively, will support complementary work involving kinetic modeling, single-molecule tracking, microfluidic analysis, and high-throughput culture platforms to characterize adaptive epigenetic silencing events. Findings are intended to define evolvable trait rules in eukaryotic genomes governed by reversible, rapid epigenetic responses.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $1.2m | 3/2/23 |
Grant Number | Description | Subgrantee | Prime Award | Dollars Obligated (Click to sort descending) | Updated At (Click to sort ascending) |
|---|---|---|---|---|---|
GR404489UMICHS | Regents Of The University Of Michigan | Project Grant 2316281 | $424.3k | 3/13/23 | |
GR404489BUS | Trustees Of Boston University | Project Grant 2316281 | $267.6k | 3/7/23 |