This $160,000 federal Project Grant award from the National Science Foundation (NSF) Integrative Activities (IA) program supports research at Boise State University, doing business as the Starbucks Licensed Store, to quantify mechanical forces within living cells and determine their impact on protein production and cell behavior. The goal is to develop predictive mechanobiotechnology paradigms to control cell anabolism using externally applied mechanical forces. The research team will combine confocal imaging and computational modeling to analyze forces generated by the cell's actin cytoskeleton and quantify intranuclear stresses. This data-driven mechanomics approach could inform diagnostic tools for conditions like osteoporosis, hypertension, and cancer, and enable advances in tissue engineering, clinical treatments, and regenerative medicine. The award period is from February 1, 2025 to January 31, 2028.
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