Project Grant RF1NS141712
- The National Institute of Neurological Disorders and Stroke, a component of the National Institutes of Health, awarded the University of North Carolina at Chapel Hill $2,676,945 on August 20, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279). The award funds research into the allostery of RAMP-CLR (receptor activity modifying protein–calcitonin receptor-like receptor) signaling in vascular cells during migraine. The project employs sophisticated genetic mouse models...
- The National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health, awarded Beth Israel Deaconess Medical Center $749,073 on August 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate meningeal sensory neuroimmune interactions underlying migraine headache. The research combines expertise in meningeal nociception and migraine pain with functional interactions between nociceptors...
- The National Institute of Neurological Disorders and Stroke awarded Beth Israel Deaconess Medical Center, Inc. $283,037 on August 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds exploratory research investigating the relationship between meningeal nociception and visual cortex hyperexcitability in migraine pathogenesis. The project employs optogenetic activation of meningeal nociceptors, two-photon calcium...
- Federal Grant Award Summary The University of Virginia received a $444,125 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, effective July 18, 2025, with an ultimate completion date of June 30, 2027. The award funds research investigating the role of progesterone receptors in migraine chronification—specifically, the mechanisms by which...
- The National Institute of Neurological Disorders and Stroke awarded the University of Southern California $415,000 on February 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the cellular mechanisms of cold allodynia in the somatosensory system. The research examines how the menthol receptor TRPM8 and associated signaling molecules, particularly artemin (ARTN) and its receptor GFRA3, mediate diverse...
- The National Institute of Neurological Disorders and Stroke awarded Brigham & Women's Hospital $745,570 on June 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the genome-wide association study (GWAS) based neurovascular etiology of migraine and its associated risk of ischemic stroke. The research addresses the gap between recent genetic discoveries identifying 123 migraine susceptibility loci and...
- The National Institute of Neurological Disorders and Stroke awarded $589,105 to Massachusetts General Hospital on August 11, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate oxytocin as an abortive and preventive therapy for migraine with aura. The project will test oxytocin efficacy in a mouse model of migraine with aura using cortical spreading depolarization. Aim 1 will elucidate oxytocin's therapeutic role in...
- The National Institute of Neurological Disorders and Stroke awarded Duke University $3,503,160 on September 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate glial-neuronal crosstalk in neuropathic pain and diabetes. The research examines how mitochondrial transfer from satellite glial cells to sensory neurons protects against neuropathic pain and how dysfunction of this process contributes to diabetic peripheral neuropathy. The project employs two specific...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded $407,113 to the University of California, Irvine on August 15, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to support development of novel KV7 channel modulators for pain therapy. This R21 exploratory research grant, which concludes July 31, 2027, will establish an empirical foundation for developing therapies targeting...
- Federal Project Grant Award Summary New York Institute of Technology received a $472,592 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), awarded August 1, 2025, with a completion date of July 31, 2028. The award funds preclinical research and development of RGIA5474, a novel α9α10 nicotinic acetylcholine receptor (nAChR) antagonist, to evaluate...
The National Institute of Neurological Disorders and Stroke awarded Duke University $3.833 million on July 22, 2026, to investigate the role of TRP ion channels in migraine pain under the Drug Use and Addiction Research Programs (CFDA 93.279). The research examines how TRPV4 calcium ion channels in meningeal mast cells and satellite glial cells contribute to migraine pain and how this contribution varies by sex. The project employs trigeminal neuron–mast cell co-culture techniques, mast cell and satellite glial cell-specific TRPV4 deletion in mice, and in-vivo approaches to test the hypothesis that TRPV4 channels in these cell types drive migraine-related pain through sex-specific mechanisms. The work addresses a gap in understanding migraine pathophysiology, as these roles of TRPV4 in the trigeminal sensory system remain incompletely characterized despite their potential relevance to pain perception and neuroinflammation. Performance occurs at Duke University's Office of Research Administration in Durham, North Carolina, with a period of performance extending from July 22, 2026, through June 30, 2030. This is a Project Grant, classified as parent award.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.8m | 7/21/26 |