This Project Grant award of $472,592 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to evaluate the potential of RGIA5474, a novel A9A10 nicotinic acetylcholine receptor (nAChR) antagonist, as a treatment for migraine. The research aims to assess RGIA5474's ability to alleviate migraine-related pain behaviors, neurochemical changes, and...
This Project Grant award of $6,154,752, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research aimed at understanding how menstrual pain and bladder hypersensitivity interact to promote chronic pelvic pain (CPP). The 3-year study, starting on September 17, 2024, will be conducted by Endeavor Health Clinical Operations, a non-profit research institute at Evanston Hospital. The project will...
This Project Grant award of $370,440 from the National Institute of Mental Health (CFDA 93.242 Mental Health Research Grants) will fund research by Dr. Crowe at Brigham & Women's Hospital to characterize the longitudinal relationship between migraine and affective disorders across the lifespan, with a focus on hormonal fluctuations. The research aims to establish migraineurs as a unique phenotype of individuals with affective disorders due to their vulnerability to hormonal changes. The...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $419,375.00 to support research on the role of the GPR37L1 receptor in chronic migraine. The funding will enable a research team at Florida Atlantic University, with a sub-award to the University of Florida, to conduct a comprehensive investigation into the involvement of GPR37L1 signaling in the neuropathology of...
This Project Grant award of $455,371 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Drug Use and Addiction Research Programs (CFDA 93.279), is funding the development and validation of a novel microchip-based platform for the discovery and characterization of migraine therapies. The key products and services to be delivered under this award include: Quantifying comprehensive neurovascular and behavioral responses to established migraine triggers and...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $475,475 to Beth Israel Deaconess Medical Center, Inc. (BIDMC) to conduct research on the pathophysiology of morning migraine. The key objectives of this 2-year award are to: 1) Define the quantitative and qualitative profiles of complement and purinergic receptors and regulators...
This Project Grant award of $2,755,796.00 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants (CFDA 93.242) program will fund a prospective longitudinal case-control study to investigate the hormonal mechanisms linking perimenopause, inflammation, and mood symptoms. The principal investigator will recruit women seeking premenopausal risk-reducing bilateral salpingo-oophorectomy (BSO) surgery and age-matched premenopausal controls having non-BSO...
This $563,934 federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research at Tufts University School of Medicine to study the role of membrane progesterone receptors (MPRs) in mediating the effects of neuroactive steroids on neuronal excitability. The project aims to investigate how different MPR isoforms contribute to the metabotropic effects of neuroactive steroids on tonic inhibition and...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under CFDA Program 93.865 Child Health and Human Development Extramural Research, aims to identify the central and peripheral mechanisms underlying endometriosis pain and the changes in pain after lesion removal surgery. The $233,250 award, granted on April 1, 2025, will fund a study focused on examining the relationships between endometriosis pain, conditioned pain...
This federal Project Grant award of $517,494.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research at Duquesne University to investigate sex-specific differences in gene expression and RNA splicing patterns in the dorsal root ganglia during pain and pain relief. The key objectives are to define the differentially expressed RNA splice isoforms of the...