Project Grant R01HL176992
- The National Institute of Neurological Disorders and Stroke awarded Duke University $3.833 million on July 22, 2026, to investigate the role of TRP ion channels in migraine pain under the Drug Use and Addiction Research Programs (CFDA 93.279). The research examines how TRPV4 calcium ion channels in meningeal mast cells and satellite glial cells contribute to migraine pain and how this contribution varies by sex. The project employs trigeminal neuron–mast cell co-culture techniques, mast cell and...
- The National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health, awarded Beth Israel Deaconess Medical Center $749,073 on August 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate meningeal sensory neuroimmune interactions underlying migraine headache. The research combines expertise in meningeal nociception and migraine pain with functional interactions between nociceptors...
- The National Institute of Neurological Disorders and Stroke awarded Beth Israel Deaconess Medical Center, Inc. $283,037 on August 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds exploratory research investigating the relationship between meningeal nociception and visual cortex hyperexcitability in migraine pathogenesis. The project employs optogenetic activation of meningeal nociceptors, two-photon calcium...
- The National Institute of Dental and Craniofacial Research awarded $310,274 to the University of North Carolina at Chapel Hill on August 28, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121). The award funds a multidimensional phenotyping study characterizing the molecular, sensory, and psychosocial factors underlying comorbid temporomandibular disorder and migraine in adolescents. The project recruits 140 youth aged 10 to 17 years with TMD myalgia, stratified by the...
- The National Institute of Neurological Disorders and Stroke awarded Brigham & Women's Hospital $745,570 on June 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the genome-wide association study (GWAS) based neurovascular etiology of migraine and its associated risk of ischemic stroke. The research addresses the gap between recent genetic discoveries identifying 123 migraine susceptibility loci and...
- Federal Grant Award Summary The University of Virginia received a $444,125 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, effective July 18, 2025, with an ultimate completion date of June 30, 2027. The award funds research investigating the role of progesterone receptors in migraine chronification—specifically, the mechanisms by which...
- The National Institute of Neurological Disorders and Stroke awarded $439,588 to the University of North Carolina at Chapel Hill on June 22, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop gene therapy approaches for cerebellar CACNA1A disorders. The award funds research into helper-dependent adenoviral vector (HDAD) delivery systems to treat CACNA1A-related cerebellar disorders, which cause severe movement problems,...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded the University of North Carolina at Chapel Hill a $222,758 Project Grant on August 7, 2025, under the Drug Use and Addiction Research Programs (CFDA 93.279) to support research through July 31, 2027. The award funds a comprehensive neuroscience investigation aimed at delineating how different molecularly defined dorsal root ganglia (DRG) neuron types contribute to pain representation...
- The National Institute of Neurological Disorders and Stroke awarded the University of North Carolina at Chapel Hill $439,069 on June 22, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to support basic research on the molecular and genetic mechanisms governing astrocyte morphological development. The research uses molecular-genetic tools and live-imaging techniques in Drosophila and zebrafish model systems to understand how...
- The National Institute of Neurological Disorders and Stroke awarded Research Triangle Institute (RTI International) $230,562 on April 17, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop neuromedin receptor 2 (NMUR2) antagonists as novel analgesics for chronic pain treatment. The award funds the establishment of a comprehensive structure-activity relationship (SAR) for two chemical series of NMUR2 antagonists, with...
The National Institute of Neurological Disorders and Stroke, a component of the National Institutes of Health, awarded the University of North Carolina at Chapel Hill $2,676,945 on August 20, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279). The award funds research into the allostery of RAMP-CLR (receptor activity modifying protein–calcitonin receptor-like receptor) signaling in vascular cells during migraine. The project employs sophisticated genetic mouse models coupled with in vitro pharmacological and cell biological assays to investigate how RAMPs allosterically modify CLR receptor signaling, with particular focus on how female sex hormones regulate this pathway. The research targets the cellular and signaling effects of CLR-RAMPS in different lymphatic vascular beds and addresses the female-predominance of chronic migraine. Findings are expected to clarify cell-specific and hormonally-responsive vascular calcitonin gene-related peptide (CGRP) signaling and inform the mechanisms of action of anti-CGRP therapies commonly prescribed for migraine treatment. Work is performed in North Carolina with a period of performance through November 30, 2030. The University of North Carolina System Office serves as the parent institution overseeing the award.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.7m | 8/19/26 |