This Project Grant award of $472,592 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to evaluate the potential of RGIA5474, a novel A9A10 nicotinic acetylcholine receptor (nAChR) antagonist, as a treatment for migraine. The research aims to assess RGIA5474's ability to alleviate migraine-related pain behaviors, neurochemical changes, and trigeminal neuron activation in mouse models induced by migraine triggers like CGRP and PACAP38. The project will also leverage A9 knockout mice to validate the role of A9A10 nAChRs in migraine pathology. Successful outcomes could establish A9A10 nAChR antagonism as a viable novel therapeutic approach for treating migraine, particularly for patients who do not respond to current treatments. The award was granted to the New York Institute of Technology (NYIT) and has a performance period from August 1, 2025 to July 31, 2028.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $472.6k | 7/22/25 |