Project Grant R01NS149672
- The National Institute of Neurological Disorders and Stroke awarded Brigham & Women's Hospital $745,570 on June 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the genome-wide association study (GWAS) based neurovascular etiology of migraine and its associated risk of ischemic stroke. The research addresses the gap between recent genetic discoveries identifying 123 migraine susceptibility loci and...
- The National Institute of Neurological Disorders and Stroke awarded Duke University $3.833 million on July 22, 2026, to investigate the role of TRP ion channels in migraine pain under the Drug Use and Addiction Research Programs (CFDA 93.279). The research examines how TRPV4 calcium ion channels in meningeal mast cells and satellite glial cells contribute to migraine pain and how this contribution varies by sex. The project employs trigeminal neuron–mast cell co-culture techniques, mast cell and...
- The National Institute of Neurological Disorders and Stroke awarded $589,105 to Massachusetts General Hospital on August 11, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate oxytocin as an abortive and preventive therapy for migraine with aura. The project will test oxytocin efficacy in a mouse model of migraine with aura using cortical spreading depolarization. Aim 1 will elucidate oxytocin's therapeutic role in...
- The National Institute of Neurological Disorders and Stroke, a component of the National Institutes of Health, awarded the University of North Carolina at Chapel Hill $2,676,945 on August 20, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279). The award funds research into the allostery of RAMP-CLR (receptor activity modifying protein–calcitonin receptor-like receptor) signaling in vascular cells during migraine. The project employs sophisticated genetic mouse models...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded Massachusetts Institute of Technology $129,168 on August 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to support research on the modulation of autonomic function by affective pain pathways. The research interrogates the role of the parabrachial-limbic circuit and...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded $415,249 to the Regents of the University of Michigan on August 7, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). This Project Grant supports a two-year research initiative (through July 31, 2027) to develop predictive measures for migraine attack onset through continuous monitoring of autonomic nervous system...
- The National Institute of Neurological Disorders and Stroke awarded The General Hospital Corporation (doing business as Massachusetts General Hospital) $322,382 on June 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research investigating cell-specific interleukin-1 receptor 1 (IL-1R1) signaling in focal and diffuse traumatic brain injury models. The research uses genetically engineered mice with precise...
- The National Institute of Neurological Disorders and Stroke awarded the University of Texas Health Science Center at Houston $1.184 million on June 18, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop a multi-modal mouse model of cluster headache. The award funds development of an animal model combining trigeminovascular (nitroglycerin injection), genetic (MERTK knockout), and hypothalamic (optogenetic) approaches to...
- The National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health, awarded $702,655 to Weill Medical College of Cornell University on June 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to advance diagnosis and treatment of occipital neuralgia through artificial intelligence and neuroimaging. The project develops NerveAI, an artificial intelligence algorithm that identifies nerve pain...
- Federal Project Grant Summary The National Institute on Aging (NIA) awarded a $317,000 Project Grant to Indiana University Indianapolis on September 1, 2025, under the Aging Research program (CFDA 93.866) to investigate chronic migraine as an early biomarker of Alzheimer's disease (AD). The research will deliver scientific knowledge regarding the mechanistic relationship between migraine disorders and AD pathology, addressing a significant gap in the field where elevated AD incidence in migraine...
The National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health, awarded Beth Israel Deaconess Medical Center $749,073 on August 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate meningeal sensory neuroimmune interactions underlying migraine headache. The research combines expertise in meningeal nociception and migraine pain with functional interactions between nociceptors and meningeal immune cells. The project employs optogenetics, two-photon calcium imaging, flow cytometry, single-cell RNA sequencing, multiplex cytokine arrays, and pain behavior analysis to study meningeal neuroimmune interactions under conditions mimicking migraine attack onset and persistent migraine. The work addresses the hypothesis that neurogenically driven inflammatory processes involving nociceptor-immune crosstalk facilitate meningeal nociception and drive migraine headache, moving beyond prior focus on vascular components of meningeal neurogenic inflammation. The award period runs through July 31, 2031, with performance in Boston, Massachusetts. The assistance type is a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $749.1k | 7/24/26 |