This federal Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) provides $326,797 to The Regents of the University of Colorado, doing business as the University of Colorado-Denver, to conduct proteomic analyses to identify differences in plasma proteins and protein networks between people with type 2 diabetes who do and do not develop mild cognitive impairment. The overarching goal is to identify potential biomarkers for risk of cognitive impairment...
The National Institute on Aging (NIA) awarded a $212,816 Project Grant (CFDA 93.866 - Aging Research) to the Hennepin Healthcare Research Institute (HHRI) in Minneapolis, MN. The grant, titled "Plasma-Based Neuronal Insulin Signaling Exosomes as a Biomarker for Cognitive Impairment in Diabetes", will investigate the relationship between impaired neuronal insulin signaling (NIS) and the risk of cognitive decline in older adults with diabetes. The project aims to leverage data from the...
This $441,612 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research by the Trustees of Boston University Medical Campus to investigate the relationship between modifiable lifestyle and clinical risk factors, digital cognitive markers, and Alzheimer's disease (AD) progression. The research aims to: Compare cross-sectional and longitudinal associations between the "Life's Essential 8" risk factor metrics and digital cognitive...
This federal Project Grant award, valued at $2,399,431.00 and effective August 1, 2024, was issued by the National Institute on Aging (CFDA 93.866 - Aging Research) to the Trustees of Boston University to develop a digital cognitive health resource based on the Boston University Alzheimer's Disease Research Center (BU ADRC) cohort. The key objectives of this project are to: 1) collect and characterize digital cognitive metrics (DCOG) for individuals at high and low risk of Alzheimer's disease,...
This Project Grant award of $302,960 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to identify individuals who would benefit most from intensive blood pressure control for preventing cognitive decline and dementia, as well as those most likely to experience serious adverse events. The award to the Harvard T.H. Chan School of Public Health will employ advanced statistical methods and pooled data from multiple large-scale randomized trials to detect...
This federal Project Grant award of $2,398,590 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to investigate the role of altered brain microcirculation and capillary endothelial cell energetics in the development of vascular cognitive impairment and dementia (VCID) observed in Alzheimer's disease (AD) and related dementias. The multidisciplinary...
The National Institute on Aging (NIA) awarded a $2,244,471 Project Grant under CFDA 93.866 (Aging Research) to Oregon Health & Science University (OHSU) to develop a first-in-class, CNS-penetrant small molecule agonist for G protein-coupled receptor 39 (GPR39) as a potential treatment for vascular cognitive impairment and dementia (VCID). The 3-year project from September 2023 to August 2026 will use in vitro and in vivo assays to identify lead compounds, determine their safety and...
This federal Project Grant award of $125,373 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to identify genetic associations between Alzheimer's disease (AD) and cardio-cerebrovascular risk factors (CVRFs) such as hypertension and diabetes. The overarching goal is to elucidate the interplay between genes, CVRFs, and AD risk, with the potential to reveal novel molecular targets for prevention and treatment strategies tailored to diverse racial/ethnic...
This $2,365,042 Project Grant award from the National Institute on Aging's Aging Research Federal Grant Program (CFDA 93.866) supports a comprehensive research study to evaluate the biological underpinnings of Alzheimer's disease and related dementias (ADRD) across the U.S. and India. The study aims to leverage harmonized data on neurodegenerative biomarkers, cognitive outcomes, and other markers to assess the interplay between biological factors, social determinants, and ADRD risk. Key...
This $2,119,771 Project Grant award from the National Institute on Aging (under CFDA 93.866 - Aging Research) will fund research at the University of Massachusetts Medical School (UMass Medical) to investigate the role of peripheral insulin resistance and inflammation in Alzheimer's disease (AD) pathogenesis. The project aims to define age-related changes in metabolism and inflammation in peripheral organs, particularly the liver, and examine how these processes impact AD-relevant...