This federal Project Grant award, valued at $2,399,431.00 and effective August 1, 2024, was issued by the National Institute on Aging (CFDA 93.866 - Aging Research) to the Trustees of Boston University to develop a digital cognitive health resource based on the Boston University Alzheimer's Disease Research Center (BU ADRC) cohort. The key objectives of this project are to: 1) collect and characterize digital cognitive metrics (DCOG) for individuals at high and low risk of Alzheimer's disease,...
This $622,401 Project Grant award, funded by the National Institute on Aging (CFDA 93.866 - Aging Research), will support a multi-arm research project to elucidate the causal sequence of brain biomarker changes leading to Alzheimer's disease (AD) and identify modifiable lifestyle factors that could delay disease onset. The key research objectives include: Developing advanced deep learning models to predict amyloid load from readily available single-shell diffusion MRI data in symptomatic and...
This federal Project Grant award of $2,494,096 from the National Institute on Aging's Aging Research program (CFDA 93.866) will fund research to develop an early detection and monitoring approach for cognitive changes related to Alzheimer's disease. The project aims to leverage web-based cognitive testing to capture high-resolution multi-day learning curves that may detect subtle preclinical memory changes. The primary awardee, Brigham & Women's Hospital Inc., will collaborate with New...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,262,375 to the University of Massachusetts to develop AI-driven digital biomarkers for early detection of Alzheimer's disease using consumer wearables. The project aims to quantify sleep, heart rate, and activity patterns in older adults with elevated genetic risk for Alzheimer's, and use AI techniques to identify composite digital features that predict Alzheimer's pathophysiology. The...
This Project Grant award of $353,391 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to validate the use of a "Personal Learning Curve" (PLC) paradigm to detect early memory failures related to Alzheimer's disease (AD) biomarkers in a large, diverse sample of older adults at risk for cognitive decline. The project will examine whether the PLC, which measures changes in learning and recall over repeated daily evaluations, can sensitively track longitudinal...
This Project Grant award, valued at $131,813, was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The award will fund research by the Trustees of Boston University, doing business as Boston University Medical Campus, to quantify the effects of poverty alleviation policies, such as the Supplemental Nutrition Assistance Program (SNAP), on the prevalence and disparities of Alzheimer's disease and related dementias (AD/ADRD). The...
This Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866) provides $5,262,301 to Trustees of Boston University to conduct the "Triangulation of Innovative Methods to END AD (TIME-AD)" project. The project aims to strengthen causal inference in observational data on modifiable Alzheimer's disease and related dementia risk factors, including alcohol use, depression, sensory impairments, and social isolation. The research will utilize...
This Project Grant award of $302,960 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to identify individuals who would benefit most from intensive blood pressure control for preventing cognitive decline and dementia, as well as those most likely to experience serious adverse events. The award to the Harvard T.H. Chan School of Public Health will employ advanced statistical methods and pooled data from multiple large-scale randomized trials to detect...
The National Institute on Aging (CFDA 93.866 Aging Research) awarded a $148,568 Project Grant to Brandeis University to conduct research on the neurobiological mechanisms underlying daily life activity participation in older adults and its linkages to Alzheimer's disease pathology. The proposed research will use a multilevel, multimodal framework to study the behavioral and neurobiological mechanisms of age-related shifts in motivation to perform cognitively effortful activities, and directly...
This Project Grant award of $4,787,820 from the National Institute on Aging (CFDA 93.866 - Aging Research) to Brown University aims to gain a better understanding of the individual- and system-level characteristics that influence diagnosis of mild cognitive impairment (MCI) and Alzheimer's disease and related dementias (ADRD), and how diagnosis can moderate the effects of cognitive decline on employment, future care, and quality of life. The key products and services to be delivered under this...
This $441,612 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research by the Trustees of Boston University Medical Campus to investigate the relationship between modifiable lifestyle and clinical risk factors, digital cognitive markers, and Alzheimer's disease (AD) progression. The research aims to:
Compare cross-sectional and longitudinal associations between the "Life's Essential 8" risk factor metrics and digital cognitive measures versus standard neuropsychological tests.
Evaluate mild cognitive impairment definitions and severity levels for predicting AD.
Identify critical timepoints of accelerated cognitive decline using the Life's Essential 8 metrics during the preclinical AD stage.
The researchers will leverage the Framingham Heart Study's extensive data on digital cognitive assessments, lifestyle factors, and Alzheimer's biomarkers to improve understanding of digital cognitive markers for early detection of cognitive decline across diverse populations. This research aims to inform strategies for monitoring cognitive health and modifiable risk factors to support early intervention for Alzheimer's disease.