Project Grant R01AG085308

Award Date 8/15/24
Completion Date 4/30/29
Dollars Obligated $721K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Worcester, MA 01655, USA
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This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $720,621 to the University of Massachusetts Medical School to investigate the role of peripheral insulin resistance and inflammation in Alzheimer's disease (AD) pathogenesis. The key objectives are to:

  1. Define age-related changes in metabolism and inflammation in peripheral organs and the brain during AD-relevant neurodegeneration in a mouse model. This includes measuring organ-specific metabolism, analyzing cellular inflammation, and correlating these factors with AD-related outcomes like plaque load, reactive gliosis, and cognitive deficits.

  2. Delineate the liver-brain connection by manipulating the macrophage interferon-interleukin 12 axis to modulate inflammatory and metabolic pathways in the liver, and examine the impact on AD-relevant neurodegeneration in the same mouse model.

The award period runs from August 15, 2024 to April 30, 2029 and aims to establish a mechanistic link between metabolic liver disease and Alzheimer's disease, with the potential to identify macrophage signaling and cytokines as therapeutic targets.

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